Technology Process of 2'-(tert-butyldimethylsilyl)-4-deacetyl-7-(triethylsilyl)-5,20-deoxy-5,20-selenapaclitaxel
There total 6 articles about 2'-(tert-butyldimethylsilyl)-4-deacetyl-7-(triethylsilyl)-5,20-deoxy-5,20-selenapaclitaxel which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) imidazole, 2.) imidazole / 1.) DMF, 60 deg C, 2 h, 2.) DMF, room temp., 1 h
2: 66 percent / Triton B / CH2Cl2; methanol / 2 h / -15 - -10 °C
3: 85 percent / CH2Cl2 / 24 h / 35 - 40 °C
4: 93 percent / Me3SiI / CH2Cl2 / 0.75 h / -78 °C
5: 96 percent / DMAP, trifluoromethanesulfonyl chloride / CH2Cl2 / 0.83 h / Ambient temperature
6: 67 percent / Li2Se / tetrahydrofuran / 2 h / -20 - 25 °C
7: 43 percent / tetrahydrofuran / 0.05 h / -78 °C
With
1H-imidazole; dmap; lithium selenide; trimethylsilyl iodide; trifluoromethane sulfonyl chloride; N-benzyl-trimethylammonium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo982095h
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 66 percent / Triton B / CH2Cl2; methanol / 2 h / -15 - -10 °C
2: 85 percent / CH2Cl2 / 24 h / 35 - 40 °C
3: 93 percent / Me3SiI / CH2Cl2 / 0.75 h / -78 °C
4: 96 percent / DMAP, trifluoromethanesulfonyl chloride / CH2Cl2 / 0.83 h / Ambient temperature
5: 67 percent / Li2Se / tetrahydrofuran / 2 h / -20 - 25 °C
6: 43 percent / tetrahydrofuran / 0.05 h / -78 °C
With
dmap; lithium selenide; trimethylsilyl iodide; trifluoromethane sulfonyl chloride; N-benzyl-trimethylammonium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo982095h
