Quercetin-d3 (Major)

Base Information

• Chemical Name: Quercetin-d3 (Major)
• CAS No.: 263711-79-1
• Molecular Formula: C₁₅H₁₀O₇
• Molecular Weight: 307.201
• Mol file: 263711-79-1.mol

Synonyms:

Chemical Property of Quercetin-d3 (Major)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Quercetin-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Quercetin-d3 is the isotope labelled analogue of Quercetin (Q509500), a flavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activit y and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle.

Technology Process of Quercetin-d3 (Major)

There total 3 articles about Quercetin-d3 (Major) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

quercetol (117-39-5,74893-81-5) → 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl-2,5,6-D3)-4H-1-benzopyran-4-one-6,8-D2 (263711-79-1)

Guidance literature:

With boron trifluoride; [D₃]phosphoric acid; In water-d2; at 55 ℃; for 48h;

DOI:10.1016/S0040-4020(99)01085-6

Reference yield: 72.0%

3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl-2,5,6-D3)-4H-1-benzopyran-4-one-6,8-D2 (263711-79-1) → 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl-2,5,6-D3)-4H-1-benzopyran-4-one (263711-79-1)

Guidance literature:

With acetyl chloride; In methanol; for 0.333333h;

DOI:10.1016/S0040-4020(99)01085-6

Reference yield:

quercetol (117-39-5,74893-81-5) → 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl-2,5,6-D3)-4H-1-benzopyran-4-one (263711-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / D₃PO₄; BF₃ / D₂O / 48 h / 55 °C

2: 72 percent / CH₃COCl / methanol / 0.33 h

With boron trifluoride; acetyl chloride; [D₃]phosphoric acid; In methanol; water-d2; 1: deuteration / 2: dedeuteration;

DOI:10.1016/S0040-4020(99)01085-6

upstream raw materials:

quercetol

Refernces

• 1、 Rasku, Sirpa,W?h?l?, Kristiina. "Synthesis of deuterium labeled polyhydroxy flavones and 3-flavonols". . p. 913 - 916. Retrieved 2007/10/03.