10.3987/COM-10-S(E)102
The research aimed to synthesize antioxidant flavonoid derivatives, specifically quercetin-caffeic acid and quercetin-curcumin conjugates, to prevent age-related macular degeneration (AMD). The study sought to enhance the antioxidative properties of the naturally occurring plant antioxidant quercetin by linking it with other plant antioxidants, caffeic acid and curcumin. The researchers designed and synthesized quercetin derivatives connected to these natural products via an appropriate linker, expecting the resulting compounds to have increased chemical stability and antioxidative activities. The study concluded with the successful synthesis of new types of antioxidants, quercetin/caffeic acid derivative 7 and quercetin/curcumin derivative 11, and planned to further compare their antioxidant properties with other known antioxidants, with ongoing studies on their activity against A2E photooxidation.
10.1016/0031-9422(90)85105-O
The research aimed to investigate the flavonoid compounds present in New Zealand Libocedrus species, specifically Libocedrus bidwillii and L. plumosa, and to assess their chemotaxonomic significance. The study's purpose was to support or challenge the existing classification of these species within the Cupressaceae family by analyzing their flavonoid profiles. The conclusions drawn from the research indicated that while the two Libocedrus species shared similar flavonoid types, they were distinct enough to be differentiated, with L. plumosa characterized by the presence of myricetin 3-rhamnoside and L. bidwillii by the presence of a di-acylated quercetin 3-rhamnoside. The chemicals used in the process included various flavonoids such as kaempferol, quercetin, apigenin, luteolin, amentoflavone, and biflavonoids like 7-O-methyl-2,3-dihydroamentoflavone.
10.1016/0031-9422(90)85389-W
The research focuses on the isolation and identification of chemical compounds from specific plant sources. In the first study, two new flavonol glycosides, kaempferol 3-rhamnoside-4’-xyloside and kaempferol 3-rhamnoside-7-xyloside, along with kaempferol, isorhamnetin, and quercetin, were identified from the fruits of Chenopodium ambrosioides. The structures of these compounds were established using spectroscopic and chemical evidence, including techniques such as IR spectroscopy, NMR spectroscopy, and mass spectrometry. The study also involved the use of various solvents and reagents for extraction, isolation, and chemical modifications of the compounds. In the second study, a new moskachan, chalepimoskachan, along with other coumarins and alkaloids, was isolated from the roots of Ruta chalepensis. The research involved the use of chromatographic methods and spectroscopic techniques to identify and characterize these compounds.
10.1016/j.bmc.2014.04.016
The research focuses on the design and discovery of flavonoid-based HIV-1 integrase inhibitors that target both the active site of the enzyme and its interaction with LEDGF/p75. The purpose of this study is to develop novel inhibitors that can combat HIV-1 by inhibiting the viral replication process, specifically the integration of viral DNA into the host genome, which is catalyzed by HIV integrase (IN). The researchers synthesized a series of flavonoid derivatives with the aim of improving the inhibitory activity against IN and disrupting the IN-LEDGF/p75 interaction, which is crucial for viral integration. The study concluded that certain flavonoids, particularly those containing a catechol or β-ketoenol structure, showed potent inhibitory activity against both the catalytic function of IN and the IN-LEDGF/p75 interaction. Notably, the introduction of a hydrophilic morpholine group at the phenolic hydroxyl position resulted in sub- to low-micromolar IN-LEDGF/p75 inhibitory activity. The chemicals used in this process included various flavonoid derivatives, such as quercetin, baicalein, genistein, luteolin, chrysin, apigenin, and naringenin, along with synthetic reagents like acetic anhydride, benzyl bromide, potassium carbonate, and palladium catalysts for the synthesis and modification of these flavonoids.
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