tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
• CAS No.: 1174020-40-6
• Molecular Formula: C10H18FNO3
• Molecular Weight: 219.256
• Hs Code.: 2933399090
• Mol file: 1174020-40-6.mol

Synonyms:tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate;(3S,4R)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-fluoro-4-hydroxy-, 1,1-diMethylethyl ester, (3S,4R)-

Chemical Property of tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

Chemical Property:

• Boiling Point: 300.8±42.0 °C(Predicted)
• PKA: 13.65±0.40(Predicted)
• PSA: 49.77000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 1.26410
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

There total 10 articles about tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl (3S)-3-fluoro-4-oxopiperidine-1-carboxylate (1450879-67-0) → (+)-(3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-40-6,955029-44-4)

Guidance literature:

With tetramethylammonium borohydride; In methanol; at 0 ℃; for 4.25h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo401352z

Reference yield:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → (+)-(3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-40-6,955029-44-4) + (-)-(3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-42-8,955029-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 - 20 °C

2: Chiralpak AD-H column / ethanol; carbon dioxide / Resolution of racemate

With sodium tetrahydroborate; In methanol; ethanol; carbon dioxide;

Reference yield:

(syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (955029-44-4) → (+)-(3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-40-6,955029-44-4) + (-)-(3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-42-8,955029-44-4)

Guidance literature:

With Chiralpak AD-H column; In ethanol; carbon dioxide; Resolution of racemate;

upstream raw materials:

(syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(3S,4R)-tert-butyl 3-fluoro-4-(tosyloxy)piperidine-1-carboxylate

(3S,4R)-3-fluoro-4-methanesulfonyloxypiperidine-1-carboxylic acid tert butyl ester

(3S,4R)-3-fluoropiperidin-4-ol hydrochloride