Trans-tert-Butyl3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate

Base Information

• Chemical Name: Trans-tert-Butyl3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate
• CAS No.: 1070896-84-2
• Molecular Formula: C11H20FNO5S
• Molecular Weight: 297.3436032
• Mol file: 1070896-84-2.mol

Synonyms:Trans-tert-Butyl3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate

Chemical Property of Trans-tert-Butyl3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate

Chemical Property:

• PSA: 81.29000
• LogP: 2.32880

Purity/Quality:

98%min ^*data from raw suppliers

TRANS-TERT-BUTYL3-FLUORO-4-(METHYLSULFONYLOXY)PIPERIDINE-1-CARBOXYLATE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trans-tert-Butyl3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate

There total 21 articles about Trans-tert-Butyl3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-(3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-42-8,955029-44-4) + methanesulfonyl chloride (124-63-0) → (3R,4S)-3-fluoro-4-methanesulfonyloxypiperidine-1-carboxylic acid tert butyl ester (1313410-87-5,1070896-84-2,1207176-25-7,1070897-23-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield: 99.0%

(+)-(3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (1174020-40-6,955029-44-4) + methanesulfonyl chloride (124-63-0) → (3S,4R)-3-fluoro-4-methanesulfonyloxypiperidine-1-carboxylic acid tert butyl ester (1070896-84-2,1207176-25-7,1070897-23-2)

Guidance literature:

With triethylamine; In dichloromethane; at -30 ℃; for 2h; Inert atmosphere;

Reference yield: 96.0%

(anti)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (955029-44-4) + methanesulfonyl chloride (124-63-0) → (anti)-3-fluoro-4-methanesulfonyloxypiperidine-1-carboxylic acid tert-butyl ester (1070896-84-2,1207176-25-7,1070897-23-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

upstream raw materials:

(syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

methanesulfonyl chloride

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

cis-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate

(trans)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate

tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

(3R,4R)-tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

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