N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

Base Information

• Chemical Name: N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
• CAS No.: 2730-52-1
• Molecular Formula: C3H7ClF3N
• Molecular Weight: 149.543
• Hs Code.: 2921199090
• Mol file: 2730-52-1.mol

Synonyms:2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE;

Chemical Property of N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

Chemical Property:

• Vapor Pressure: 138mmHg at 25°C
• Melting Point: >200 °C (sublm)(Solv: ethanol (64-17-5))
• Boiling Point: 67.8°C at 760 mmHg
• PSA: 12.03000
• LogP: 1.96100
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trifluoro-N-methylethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

There total 1 articles about N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

N-methyl-2,2,2-trifluoroacetamide (815-06-5) → N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride (2730-52-1)

Guidance literature:

N-methyl-2,2,2-trifluoroacetamide; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

With Glauber's salt; In diethyl ether; at -10 ℃;

With hydrogenchloride; In diethyl ether;

Reference yield: 89.9%

1-methyl-5-(2-phenyl[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid (1380329-77-0) + N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride (2730-52-1) → 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-[methyl-(2,2,2-trifluoro-ethyl)-amide] 3-[(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-amide] (1380330-25-5)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; at 60 ℃; for 18h;

Reference yield: 75.0%

ethyl 7-chloro-1-(2,4-difluorophenyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (157373-29-0) + N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride (2730-52-1) → ethyl 1-(2,4-difluorophenyl)-7-[methyl(2,2,2-trifluoroethyl)amino]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 - 70 ℃; for 96h;

upstream raw materials:

N-methyl-2,2,2-trifluoroacetamide

Downstream raw materials:

methyl-nitroso-(2,2,2-trifluoro-ethyl)-amine

2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-6-(ethyl(2,2,2-trifluoroethyl)amino)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile

2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-4-(4-(2-hydroxyethoxy)phenyl)-6-(methyl(2,2,2-trifluoroethyl)amino)pyridine-3,5-dicarbonitrile

2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-[methyl-(2,2,2-trifluoro-ethyl)-amide] 3-[(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-amide]

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