ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Base Information

Chemical Name:ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER
CAS No.:745836-21-9
Molecular Formula:C₉H₁₅NO₂
Molecular Weight:169.224
Hs Code.:
Mol file:745836-21-9.mol

Synonyms:ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Suppliers and Price of ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(1R,4S,7R)-rel-ethyl2-azabicyclo[2.2.1]heptane-7-carboxylate 97%
1g
$ 369.00

Crysdot
(1R,4S,7R)-rel-ethyl2-azabicyclo[2.2.1]heptane-7-carboxylate 97%
5g
$ 1112.00

American Custom Chemicals Corporation
ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 504.36

Total 6 raw suppliers

Chemical Property of ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Boiling Point:234.1±23.0 °C(Predicted)
PKA:10.14±0.40(Predicted)
PSA：38.33000
Density:1.089±0.06 g/cm3(Predicted)
LogP:0.87630

Purity/Quality:

99% ^*data from raw suppliers

(1R,4S,7R)-rel-ethyl2-azabicyclo[2.2.1]heptane-7-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

There total 16 articles about ANTI-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 745836-32-2
anti-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester

: 745836-21-9
anti-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 24h;
DOI:10.1021/jo0492564

Reference yield: 61.0%

: 745836-32-2
syn-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester

: 745836-21-9
syn-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jo0492564

Reference yield:

: 112375-05-0,150851-98-2
N-benzyl-2-azanorborn-5-ene

: 745836-21-9
syn-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: Br₂ / CH₂Cl₂; acetonitrile / -78 - 20 °C

2: 93 percent / Red-Al / toluene; tetrahydrofuran / 2 h / -10 °C

3: 66 percent / 18-crown-6 / dimethylformamide / 24 h / 110 °C

4: HCl / H₂O / 65 h / 90 °C

5: SOCl₂ / 6 h / 40 °C

6: 0.5 h / 20 °C

7: 46 percent / NaOEt; HMPA / ethanol / 24 h / 65 °C

8: 61 percent / H₂ / Pd/C / methanol

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; 18-crown-6 ether; hydrogen; bromine; sodium ethanolate; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo0492564