Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-((Z)-1,5-dimethyl-hexa-1,4-dienyl)-5,5-dimethyl-cyclohexyl ester
There total 7 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-((Z)-1,5-dimethyl-hexa-1,4-dienyl)-5,5-dimethyl-cyclohexyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
2: 1.) cuprous iodide / 1.) -78 deg C, 10 min, ether, 2.) -20 deg C, 4 h
3: reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol / CH2Cl2 / 1.) -78 deg C, 20 min, 2.) 0 deg C, 20 min
4: reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol / different amount of reagent; determination of optical purity; 1.) -78 deg C, 20 min, 2.) 0 deg C, 20 min
5: dimethylaminopyridine / CH2Cl2; pyridine / 6 h / Ambient temperature
With
copper(l) iodide; dimethyl zinc(II); (R)-1,1'-Bi-2-naphthol;
dmap;
In
pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)90599-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) cuprous iodide / 1.) -78 deg C, 10 min, ether, 2.) -20 deg C, 4 h
2: reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol / CH2Cl2 / 1.) -78 deg C, 20 min, 2.) 0 deg C, 20 min
3: reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol / different amount of reagent; determination of optical purity; 1.) -78 deg C, 20 min, 2.) 0 deg C, 20 min
4: dimethylaminopyridine / CH2Cl2; pyridine / 6 h / Ambient temperature
With
copper(l) iodide; dimethyl zinc(II); (R)-1,1'-Bi-2-naphthol;
dmap;
In
pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)90599-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol / CH2Cl2 / 1.) -78 deg C, 20 min, 2.) 0 deg C, 20 min
2: reagent derived from dimethylzinc and (R)-(+)-1,1'-bi-2-naphthol / different amount of reagent; determination of optical purity; 1.) -78 deg C, 20 min, 2.) 0 deg C, 20 min
3: dimethylaminopyridine / CH2Cl2; pyridine / 6 h / Ambient temperature
With
dimethyl zinc(II); (R)-1,1'-Bi-2-naphthol;
dmap;
In
pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)90599-X
