2-METHYLISOINDOLIN-1-ONE

Base Information

• Chemical Name: 2-METHYLISOINDOLIN-1-ONE
• CAS No.: 5342-91-6
• Molecular Formula: C9H9 N O
• Molecular Weight: 147.177
• Hs Code.: 2933790090
• Mol file: 5342-91-6.mol

Synonyms:Phthalimidine,2-methyl- (6CI,7CI,8CI); 1-Oxo-2-methylisoindoline;2-Methyl-2,3-dihydro-1H-isoindol-1-one; 2-Methylisoindolin-1-one;N-Methylphthalimidine; NSC 3677

Chemical Property of 2-METHYLISOINDOLIN-1-ONE

Chemical Property:

• Vapor Pressure: 0.00239mmHg at 25°C
• Boiling Point: 288.1°C at 760 mmHg
• Flash Point: 135.3°C
• PSA: 20.31000
• Density: 1.167g/cm³
• LogP: 1.21010

Purity/Quality:

99% ^*data from raw suppliers

2-Methylisoindolin-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYLISOINDOLIN-1-ONE

There total 12 articles about 2-METHYLISOINDOLIN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

oct-1-ene (111-66-0,25068-25-1) + n-propyl benzyl(methyl)carbamate (160094-23-5) → 2-methylisoindolin-1-one (5342-91-6) + (E)-N-benzyl-N-methylnon-3-enamide (1520080-44-7)

Guidance literature:

With phosphorus pentoxide; In 1,2-dichloro-ethane; at 0 - 84 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol403142d

Reference yield: 75.0%

oct-1-ene (111-66-0,25068-25-1) + propan-2-yl benzyl(methyl)carbamate (104272-97-1) → 2-methylisoindolin-1-one (5342-91-6) + (E)-N-benzyl-N-methylnon-3-enamide (1520080-44-7)

Guidance literature:

With phosphorus pentoxide; In 1,2-dichloro-ethane; at 0 - 84 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol403142d

Reference yield: 61.0%

1-hexene (592-41-6,25067-06-5) + propan-2-yl benzyl(methyl)carbamate (104272-97-1) → 2-methylisoindolin-1-one (5342-91-6) + (E)-N-(4-bromobenzyl)-N-methylhept-3-enamide (1520080-45-8)

Guidance literature:

With phosphorus pentoxide; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol403142d

upstream raw materials:

N-methylphthalimide

N-chloro-N-methyl-α-chloroorthotoluamide

ethanol

sulfuric acid

Downstream raw materials:

2-methyl-3-phenyl-2,3-dihydro-1H-isoindol-1-one

3-hydroxy-2-methyl-3-phenyl-2,3-dihydro-isoindol-1-one

N-methylphthalimide