[(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine

Base Information

• Chemical Name: [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine
• CAS No.: 137944-13-9
• Molecular Formula: C₁₉H₃₂N₃OPS
• Molecular Weight: 381.522
• Mol file: 137944-13-9.mol

Synonyms:

Chemical Property of [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine

There total 5 articles about [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,R)-N,N'-dimethyl-1,2-diaminocyclohexane (68737-65-5) → [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine (137944-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 96 h / 150 °C

2: toluene / Ambient temperature

3: sulphur

With sulfur; In toluene;

DOI:10.1021/jo00030a034

Reference yield:

(R,R)-(2-ethoxycarbonylaminocyclohexyl)carbamic acid ethyl ester (75730-13-1) → [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine (137944-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / LiAlH₄ / tetrahydrofuran / 36 h / Heating

2: 85 percent / 96 h / 150 °C

3: toluene / Ambient temperature

4: sulphur

With lithium aluminium tetrahydride; sulfur; In tetrahydrofuran; toluene;

DOI:10.1021/jo00030a034

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → [(1R,2S)-2-{(R,R)-(1,3-dimethyl-2-thioxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine (137944-13-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / aqu. NaOH / toluene / 3 h / Ambient temperature

2: 84 percent / LiAlH₄ / tetrahydrofuran / 36 h / Heating

3: 85 percent / 96 h / 150 °C

4: toluene / Ambient temperature

5: sulphur

With sodium hydroxide; lithium aluminium tetrahydride; sulfur; In tetrahydrofuran; toluene;

DOI:10.1021/jo00030a034

upstream raw materials:

[(1R,2S)-2-{(R,R)-(1,3-dimethyl-octahydro-benzo[1,3,2]diazaphosphol-2-yloxy)}-1-methyl-2-phenyl-ethyl]dimethyl-amine

(R,R)-N,N'-dimethyl-1,2-diaminocyclohexane

(R,R)-(2-ethoxycarbonylaminocyclohexyl)carbamic acid ethyl ester

(1R,2R)-1,2-diaminocyclohexane