Glycine, N-[1-[N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-phenylalanyl]-L-prolyl ]-, 2-oxo-2-phenylethyl ester

Base Information

• Chemical Name: Glycine, N-[1-[N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-phenylalanyl]-L-prolyl ]-, 2-oxo-2-phenylethyl ester
• CAS No.: 100008-22-8
• Molecular Formula: C₃₄H₄₂N₄O₈
• Molecular Weight: 634.729
• Mol file: 100008-22-8.mol

Synonyms:

Chemical Property of Glycine, N-[1-[N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-phenylalanyl]-L-prolyl ]-, 2-oxo-2-phenylethyl ester

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[1-[N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-phenylalanyl]-L-prolyl ]-, 2-oxo-2-phenylethyl ester

There total 5 articles about Glycine, N-[1-[N-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-phenylalanyl]-L-prolyl ]-, 2-oxo-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → Boc-Pro-Phe-Pro-Gly-OPac (100008-22-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent

2: HCl (1.1 mol/l) / acetic acid

4: HCl (1.1 mol/l) / acetic acid

With hydrogenchloride; In acetic acid;

Reference yield:

glycine phenacyl ester (83316-92-1) → Boc-Pro-Phe-Pro-Gly-OPac (100008-22-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent

2: HCl (1.1 mol/l) / acetic acid

4: HCl (1.1 mol/l) / acetic acid

With hydrogenchloride; In acetic acid;

Reference yield:

[((S)-Pyrrolidine-2-carbonyl)-amino]-acetic acid 2-oxo-2-phenyl-ethyl ester → Boc-Pro-Phe-Pro-Gly-OPac (100008-22-8)

Guidance literature:

Multi-step reaction with 3 steps

2: HCl (1.1 mol/l) / acetic acid

With hydrogenchloride; In acetic acid;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

glycine phenacyl ester

Boc-Pro-Gly-OPac

Boc-Phe-Pro-Gly-OPac

Downstream raw materials:

des-Tyr¹-β-casomorphin-5

β-casomorphine monohydrochloride

Boc-Tyr-Pro-Phe-Pro-Gly-OH

N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanyl-L-prolylglycine

Refernces