Boc-Pro-Gly-OPac

Base Information

• Chemical Name: Boc-Pro-Gly-OPac
• CAS No.: 100008-20-6
• Molecular Formula: C₂₀H₂₆N₂O₆
• Molecular Weight: 390.436
• Mol file: 100008-20-6.mol

Synonyms:

Chemical Property of Boc-Pro-Gly-OPac

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Pro-Gly-OPac

There total 2 articles about Boc-Pro-Gly-OPac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + glycine phenacyl ester (83316-92-1) → Boc-Pro-Gly-OPac (100008-20-6)

Guidance literature:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + TFA·H-Gly-OPac → Boc-Pro-Gly-OPac (100008-20-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h; Reagent/catalyst;

DOI:10.1002/psc.2544

Reference yield:

Boc-Pro-Gly-OPac (100008-20-6) → [((S)-Pyrrolidine-2-carbonyl)-amino]-acetic acid 2-oxo-2-phenyl-ethyl ester

Guidance literature:

With hydrogenchloride; In acetic acid;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

glycine phenacyl ester

Downstream raw materials:

{[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-acetic acid 2-oxo-2-phenyl-ethyl ester

N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanyl-L-prolylglycine

Boc-Phe-Pro-Gly-OPac

Boc-Pro-Phe-Pro-Gly-OPac

Refernces

• 1、 Hartrodt,Neubert,Matthies,et al.. "Optimization of the β-casomorphine-5 synthesis". . p. 201 - 201. Retrieved 2007/10/02.