(1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate

Base Information

• Chemical Name: (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate
• CAS No.: 134308-25-1
• Molecular Formula: 2C₈H₈O₃*C₈H₁₈N₂
• Molecular Weight: 446.544
• Mol file: 134308-25-1.mol

Synonyms:

Chemical Property of (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate

There total 3 articles about (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimethylcyclohexene (1674-10-8) → (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate (134308-25-1,134308-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 28 percent / N₂O₄ / diethyl ether / 6 h / 0 °C

2: H₂ / Pd(OH)2-C / acetic acid / 2280 Torr

3: ethanol / 0.5 h / Heating

With hydrogen; dinitrogen tetraoxide; palladium hydroxide - carbon; In diethyl ether; ethanol; acetic acid;

DOI:10.1016/S0040-4039(00)74310-3

Reference yield:

trans-1,2-Dimethyl-1,2-dinitrocyclohexane (116725-27-0) → (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate (134308-25-1,134308-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd(OH)2-C / acetic acid / 2280 Torr

2: ethanol / 0.5 h / Heating

With hydrogen; palladium hydroxide - carbon; In ethanol; acetic acid;

DOI:10.1016/S0040-4039(00)74310-3

Reference yield:

(S)-Mandelic acid (17199-29-0) + trans-N,N’-dimethylcyclohexane-1,2-diamine (134150-25-7,134234-69-8,134234-70-1) → (1R,2R)-1,2-Dimethyl-1,2-cyclohexanediammonium bis (S)-mandelate (134308-25-1,134308-26-2)

Guidance literature:

In ethanol; for 0.5h; Heating;

DOI:10.1016/S0040-4039(00)74310-3

upstream raw materials:

(S)-Mandelic acid

trans-N,N’-dimethylcyclohexane-1,2-diamine

1,2-dimethylcyclohexene

trans-1,2-Dimethyl-1,2-dinitrocyclohexane

Downstream raw materials:

(1R,2R)-1,2-Dimethyl-1,2-cyclohexanediamine