Technology Process of 2-<4'-ethyl-2'-methoxy-1'-<2-(1,4,5-trimethoxynaphthalene)>phenyl>-4,4-dimethyl-2,3-dihydro-oxazole
There total 7 articles about 2-<4'-ethyl-2'-methoxy-1'-<2-(1,4,5-trimethoxynaphthalene)>phenyl>-4,4-dimethyl-2,3-dihydro-oxazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
for 15h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / potassium carbonate / acetone / 20 h / Heating
2: 96 percent / sodium hydride (80percent oil) / tetrahydrofuran / 1.5 h / Heating
3: 1.) magnesium turnings, iodine; 2.) iodomethane / 1.) THF, reflux; 2.) THF, reflux, then r.t. 2 h
4: 100 percent / H2 / palladium-on-carbon / ethanol / Ambient temperature
5: 4.6 g / thionyl chloride / 8 h / Heating
6: CH2Cl2 / Ambient temperature
7: 81 percent / tetrahydrofuran / 15 h / Ambient temperature
With
thionyl chloride; hydrogen; iodine; sodium hydride; potassium carbonate; magnesium; methyl iodide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) magnesium turnings, iodine; 2.) iodomethane / 1.) THF, reflux; 2.) THF, reflux, then r.t. 2 h
2: 100 percent / H2 / palladium-on-carbon / ethanol / Ambient temperature
3: 4.6 g / thionyl chloride / 8 h / Heating
4: CH2Cl2 / Ambient temperature
5: 81 percent / tetrahydrofuran / 15 h / Ambient temperature
With
thionyl chloride; hydrogen; iodine; magnesium; methyl iodide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
