Technology Process of (S)-2-(benzyloxymethyl)butanal
There total 6 articles about (S)-2-(benzyloxymethyl)butanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16.5 h / -10 - 20 °C
2.1: sodium hydride / nujol; tetrahydrofuran / 16.5 h / 0 - 20 °C
2.2: 3 h / 0 - 20 °C
3.1: Amano lipase / di-isopropyl ether / 12 h / 20 °C / Enzymatic reaction
4.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 16 h / 0 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
6.2: -78 - 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; trifluorormethanesulfonic acid; Amano lipase; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; nujol; dichloromethane; di-isopropyl ether; cyclohexane;
6.1: |Swern Oxidation / 6.2: |Swern Oxidation;
DOI:10.1039/c3ob27508f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / nujol; tetrahydrofuran / 16.5 h / 0 - 20 °C
1.2: 3 h / 0 - 20 °C
2.1: Amano lipase / di-isopropyl ether / 12 h / 20 °C / Enzymatic reaction
3.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 16 h / 0 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
5.2: -78 - 20 °C
With
oxalyl dichloride; trifluorormethanesulfonic acid; Amano lipase; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; nujol; dichloromethane; di-isopropyl ether; cyclohexane;
5.1: |Swern Oxidation / 5.2: |Swern Oxidation;
DOI:10.1039/c3ob27508f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 16 h / 0 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
3.2: -78 - 20 °C
With
oxalyl dichloride; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; cyclohexane;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1039/c3ob27508f
