Glycine, N-[O-(phenylmethyl)-L-tyrosyl]-, ethyl ester, monohydrochloride

Base Information

• Chemical Name: Glycine, N-[O-(phenylmethyl)-L-tyrosyl]-, ethyl ester, monohydrochloride
• CAS No.: 100039-27-8
• Molecular Formula: C20H24N2O4.ClH
• Molecular Weight: 392.882
• Mol file: 100039-27-8.mol

Synonyms:

Chemical Property of Glycine, N-[O-(phenylmethyl)-L-tyrosyl]-, ethyl ester, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[O-(phenylmethyl)-L-tyrosyl]-, ethyl ester, monohydrochloride

There total 1 articles about Glycine, N-[O-(phenylmethyl)-L-tyrosyl]-, ethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-Tyr(OBzl)-Gly-OEt (40356-35-2) → Tyr(Bzl)-Gly-OEt hydrochloride (100039-27-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 0.333333h;

DOI:10.1021/jm00138a009

Reference yield: 91.0%

BOC-O-benzyl-L-serine (23680-31-1) + Tyr(Bzl)-Gly-OEt hydrochloride (100039-27-8) → Boc-Ser(Bzl)-Tyr(Bzl)-Gly-OEt (50715-56-5)

Guidance literature:

With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 16h;

DOI:10.1021/jm00138a009

Reference yield:

Tyr(Bzl)-Gly-OEt hydrochloride (100039-27-8) → Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH (50715-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / TEA, dicycloxexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HBT) / CH₂Cl₂ / 16 h / 0 °C

2: 4 N KOH / methanol / 0.83 h / 0 °C

With potassium hydroxide; TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm00138a009

upstream raw materials:

BOC-Tyr(OBzl)-Gly-OEt

Downstream raw materials:

Boc-Ser(Bzl)-Tyr(Bzl)-Gly-OEt

Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH

Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl

Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl

Refernces