40356-35-2

Upstream product

• 459-73-4 GlyOEt*HCl 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 147362-63-8 Boc-Tyr-Gly-NHOH 
• 88621-32-3 Boc-Tyr(Bzl)-Gly-Glyt-Phe-Leu-OBzl 
• 5845-66-9 3-(S)-(4-hydroxy-benzyl)-piperazine-2,5-dione 
• 1628630-12-5 cyclo(L-tyrosine(OBn)-glycine) 
• 54905-47-4 pGlu-His-Trp-Ser-Tyr-Gly-Leu 
• 84636-31-7 C₆₃H₇₀N₁₀O₁₁ 
• 77112-05-1 Boc-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl 
• 84636-30-6 Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl 
• 50715-56-5 Boc-Ser(Bzl)-Tyr(Bzl)-Gly-OEt 
• 50715-57-6 Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH 
• 106677-21-8 Boc-Tyr(Bzl)-Gly-NHOH 
• 100039-27-8 Tyr(Bzl)-Gly-OEt hydrochloride 
• 41296-45-1 N-Boc-Tyr(Bn)-Gly-OH 

Relevant academic research and scientific papers

Synthesis and conformational characterization of diketopiperazines bearing a benzyl moiety

Diketopiperazines bearing a benzyl moiety with different para-substituents were synthesized and analyzed by 1HNMR spectroscopy. All of these diketopiperazines were found to adopt a folded conformation according to the upfield chemical shift of the cis-proton (cis to the benzyl moiety) due to a shielding effect in the 1HNMR spectra. An intramolecular CH-π interaction appears to be an important factor for the folded conformation due to the effects of para-substituents on the benzyl group.

5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP): A highly efficient immonium type peptide coupling reagent

HOBt-based immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and biologically active peptides both in solution

A new coupling reagent for peptide synthesis. Benzotriazolvyloxy-bis (pyrroltdino) -carbonium hexaflouorophosphate (BBC)

Benzotriazolyloxy-bis(pyrrolidino)-carbonium hexa- fluorophosphate (BBC) is found to be a new excellent coupling reagent devoid of cytotoxic by-product instead of HBTU and BOP. It has been applied in the solution and solid phase peptide synthesis.

Inhibition of urease activity by dipeptidyl hydroxamic acids

A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH: X = amino acid residues) was synthesized, and the inhibitory activity against Jack bean and.Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease wit

PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE A NEW EFFICIENT COUPLING REAGENT IN PEPTIDE CHEMISTRY

Pentafluorophenyl diphenylphosphinate was found to be a new efficient coupling reagent for the racemization-free synthesis of peptides.It has been applied in both the solution and the solid phase peptide synthesis.

2,2'-CARBONYL-BIS(3,5-DIOXO-4-METHYL-1,2,4-OXADIAZOLIDINE) : I- A NEW REAGENT FOR THE PREPARATION OF CARBAMATES AND AMIDES, APPLICATION TO THE SYNTHESIS OF DIPEPTIDES.

2,2'-Carbonyl bis (3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) was prepared and used for the synthesis of various carbamates and dipeptides.

Studies on Amino Acids and Peptides. Part 6. Methods for Introducing Thioamide Bonds into the Peptide Backbone: Synthesis of the Four Monothio Analogues of Leucine Enkephalin

A methodology for preparing peptide analogues in which a thioamide bond replaces the normal amide bond is described.Thus, the synthesis of the three leucine enkephalin analogues 4>-, 2>-, and 1>-leucine enke

An Approach to the Elucidation of Metabolic Breakdown Products of the Luteinizing Hormone-Releasing Hormone

Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGlu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).We have synthesized fragments 2-10 and successfully separated all ten metabolites and LH-RH by high-performance liquid chromatography (HPLC) with μBondapak C18 column.In a test of viability of the method, cochromatography of fragments 1-10 and LH-RH with the products of chymotryptic digestion of tritiated LH-RH showed radioactive peaks corresponding to the expected products, fragments 3 and 5.Analysis of the products of incubation of a rat kidney homogenate supernatant with LH-RH showed fragments 1-4 and LH-RH.The finding of breakdown at position 4 uncovers a new site of LH-RH breakdown and points the way to the design of potential LH-RH antagonists and agonists where the 4 position would be substituted with unnatural amino acids to prevent breakdown.