2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

Base Information

• Chemical Name: 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide
• CAS No.: 1428949-80-7
• Molecular Formula: C₂₄H₃₁FN₄O₂
• Molecular Weight: 426.534
• Mol file: 1428949-80-7.mol

Synonyms:

Chemical Property of 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

There total 6 articles about 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide + 2-fluoroethyl tosylate (383-50-6) → 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide (1428949-80-7)

Guidance literature:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.166667h; Microwave irradiation;

2-fluoroethyl tosylate; In tetrahydrofuran; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/jm4001874

Reference yield:

3-oxo-3-(4'-methoxyphenyl)propanenitrile (3672-47-7) → 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide (1428949-80-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide; potassium iodide / ethanol; water / 0.67 h / 80 °C / Microwave irradiation

2.1: acetic acid; hydrazine / ethanol / 0.67 h / 90 °C / Microwave irradiation

3.1: ethanol / 0.75 h / 180 °C / Microwave irradiation

4.1: hydrogen bromide / water / 0.67 h / 110 °C / Microwave irradiation

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 - 20 °C / Microwave irradiation

5.2: 0.5 h / 120 °C / Microwave irradiation

With hydrogen bromide; sodium hydride; acetic acid; potassium iodide; sodium hydroxide; hydrazine; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm4001874

Reference yield:

2-Chloro-N,N-diethylacetamide (2315-36-8) → 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide (1428949-80-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide; potassium iodide / ethanol; water / 0.67 h / 80 °C / Microwave irradiation

2.1: acetic acid; hydrazine / ethanol / 0.67 h / 90 °C / Microwave irradiation

3.1: ethanol / 0.75 h / 180 °C / Microwave irradiation

4.1: hydrogen bromide / water / 0.67 h / 110 °C / Microwave irradiation

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 - 20 °C / Microwave irradiation

5.2: 0.5 h / 120 °C / Microwave irradiation

With hydrogen bromide; sodium hydride; acetic acid; potassium iodide; sodium hydroxide; hydrazine; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm4001874

upstream raw materials:

3-oxo-3-(4'-methoxyphenyl)propanenitrile

2-Chloro-N,N-diethylacetamide

2-fluoroethyl tosylate

N,N-diethyl-[3-cyano-4-(4-methoxyphenyl)-4-oxo]butanamide