Technology Process of (5Z,8Z,13S)-13-Benzyloxytetradeca-5,8-dienoic acid
There total 6 articles about (5Z,8Z,13S)-13-Benzyloxytetradeca-5,8-dienoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) NaH / 1) DMF, a) 5 to 20 deg C, 1 h, b) 20 deg C, 30 min, 2) 5-15 deg C, 30 min
2: p-TsOH / tetrahydrofuran; H2O; propan-2-ol / 1 h / Heating
3: 1) sodium hexamethyldisilazide / 1) THF, toluene, 2 h, 25 deg C, 2) THF, a) -100 deg C, 30 min, b) to 25 deg C, 3 h
4: p-TsOH / tetrahydrofuran; H2O / 0.08 h / Heating
5: tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / -100 to 0 deg C, 3-4 h
With
sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; isopropyl alcohol; toluene;
DOI:10.1055/s-1993-25874
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) NaH / 1) DMF, a) 5 to 20 deg C, 1 h, b) 20 deg C, 30 min, 2) 5-15 deg C, 30 min
2: p-TsOH / tetrahydrofuran; H2O; propan-2-ol / 1 h / Heating
3: 1) sodium hexamethyldisilazide / 1) THF, toluene, 2 h, 25 deg C, 2) THF, a) -100 deg C, 30 min, b) to 25 deg C, 3 h
4: p-TsOH / tetrahydrofuran; H2O / 0.08 h / Heating
5: tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / -100 to 0 deg C, 3-4 h
With
sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; isopropyl alcohol; toluene;
DOI:10.1055/s-1993-25874
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) sodium hexamethyldisilazide / 1) THF, toluene, 2 h, 25 deg C, 2) THF, a) -100 deg C, 30 min, b) to 25 deg C, 3 h
2: p-TsOH / tetrahydrofuran; H2O / 0.08 h / Heating
3: tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / -100 to 0 deg C, 3-4 h
With
sodium hexamethyldisilazane; toluene-4-sulfonic acid;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; toluene;
DOI:10.1055/s-1993-25874
