N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide

Base Information

• Chemical Name: N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide
• CAS No.: 138989-96-5
• Molecular Formula: C₂₁H₁₉ClF₄N₄O₂
• Molecular Weight: 470.854
• Mol file: 138989-96-5.mol

Synonyms:

Chemical Property of N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide

There total 3 articles about N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-fluoro-4-(trifluoromethyl)benzoyl chloride (126917-10-0) + (2R*,3R*)-2-(4-Chlorophenyl)-3-(N-methylamino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (138990-00-8) → N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide (138989-96-5)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1248/cpb.39.2581

Reference yield:

1-[(2R,3S)-2-(4-Chloro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole (126917-50-8,127001-02-9,132563-78-1) → N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide (138989-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.45 g / methanol / 24 h / 70 °C

2: 54 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With triethylamine; In methanol; dichloromethane;

DOI:10.1248/cpb.39.2581

Reference yield:

1-[(4S,5S)-5-(4-Chloro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole (126917-21-3,132507-91-6) → N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide (138989-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / LiAlH₄ / tetrahydrofuran / 0 °C

2: 54 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.39.2581

upstream raw materials:

2-fluoro-4-(trifluoromethyl)benzoyl chloride

(2R*,3R*)-2-(4-Chlorophenyl)-3-(N-methylamino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

1-[(2R,3S)-2-(4-Chloro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole

1-[(4S,5S)-5-(4-Chloro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole