Technology Process of Methyl 11-hydroxyundec-9-ynoate
There total 1 articles about Methyl 11-hydroxyundec-9-ynoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 89 percent / LiAlH4 / tetrahydrofuran / 2 h / -10 - 15 °C
2: 86 percent / HBr / 1 h / 100 - 110 °C
3: 1.) LiNH2 / 1.) liq. NH3, from -50 deg C to -40 deg C, 0.5 h, 2.) THF, liq. NH3, a) -33 deg C, 1 h, b) RT, 4 h
4: NaI / dimethylsulfoxide / 1.5 h / 100 - 125 °C
5: 10percent aq. NaOH / 5 h / 90 - 100 °C
With
sodium hydroxide; lithium aluminium tetrahydride; lithium amide; hydrogen bromide; sodium iodide;
In
tetrahydrofuran; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: PPh3, CBr4 / CH2Cl2 / 1 h / 0 °C
2: 92 percent / CuI, NaI, K2CO3 / dimethylformamide
3: H2, quinoline / Pd/CaCO3 / benzene / 7 °C
4: aq. NaOH / methanol / 2 h / Ambient temperature
With
quinoline; sodium hydroxide; copper(l) iodide; carbon tetrabromide; hydrogen; potassium carbonate; triphenylphosphine; sodium iodide;
Lindlar's catalyst;
In
methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
