4-(Benzyloxy)-2-(chloromethyl)pyridine

Base Information

Chemical Name:4-(Benzyloxy)-2-(chloromethyl)pyridine
CAS No.:100375-81-3
Molecular Formula:C13H12ClNO
Molecular Weight:233.697
Hs Code.:
DSSTox Substance ID:DTXSID70513470
Wikidata:Q82373311
Mol file:100375-81-3.mol

Synonyms:4-(BENZYLOXY)-2-(CHLOROMETHYL)PYRIDINE;100375-81-3;2-(chloromethyl)-4-phenylmethoxypyridine;SCHEMBL1932255;DTXSID70513470;YXPNGNMGUJXKHA-UHFFFAOYSA-N;AKOS010508701;AB60017

Suppliers and Price of 4-(Benzyloxy)-2-(chloromethyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(Benzyloxy)-2-(chloromethyl)pyridine

Chemical Property:

PSA：22.12000
LogP:3.39940
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:233.0607417
Heavy Atom Count:16
Complexity:194

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC(=NC=C2)CCl

Technology Process of 4-(Benzyloxy)-2-(chloromethyl)pyridine

There total 3 articles about 4-(Benzyloxy)-2-(chloromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63071-11-4
4-(benzyloxy)-2-(hydroxymethyl)pyridine

: 100375-81-3
4-benzyloxy-2-chloromethyl-pyridine

Guidance literature:: With thionyl chloride; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/jm00081a004

Reference yield:

: 63071-08-9
4-(benzyloxy)-2-picoline N-oxide

: 100375-81-3
4-benzyloxy-2-chloromethyl-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / 120 °C

2: 2N aq. NaOH / methanol / 2 h / 25 °C

3: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; acetic acid; In methanol; dichloromethane;
DOI:10.1021/jm00081a004

Reference yield:

: 63071-05-6
acetic acid-(4-benzyloxy-[2]pyridylmethyl ester)

: 100375-81-3
4-benzyloxy-2-chloromethyl-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 2N aq. NaOH / methanol / 2 h / 25 °C

2: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;
DOI:10.1021/jm00081a004