63071-08-9

Upstream product

• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 20194-18-7 sodium phenyl-methanolate 
• 931-19-1 2-methylpyridine N-oxide 

Downstream Products

• 122541-88-2 8-(4-phenylazo-benzoyloxy)-1-(4-phenylazo-benzoyloximethyl)-3-[2]piperidyl-octahydro-quinolizin 
• 101293-91-8 (4-benzyloxy-[2]pyridyl)-acetic acid ethyl ester 
• 111371-87-0 2-(4-Benzyloxy-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 
• 111371-65-4 2-(4-Benzyloxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 
• 100375-81-3 4-benzyloxy-2-chloromethyl-pyridine 
• 175849-32-8 4-benzyloxy-2-(acetylthio)methylpyridine 
• 175849-34-0 (4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol 
• 785026-23-5 N-methyl-2-(mercaptomethyl)-4-pyridone 
• 63071-11-4 4-(benzyloxy)-2-(hydroxymethyl)pyridine 
• 107624-22-6 4-(benzyloxy)-2-methylpyridine 
• 63071-05-6 acetic acid-(4-benzyloxy-[2]pyridylmethyl ester) 

Relevant academic research and scientific papers

Tricyclic compounds having sPLA2-inhibitory activities

The present invention provides a compound having sPLA2inhibiting activity. The compound represented by the formula (I): wherein R1is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2is CONH2or CONHNH2; one of R3and R4is —(L2)-(acidic group) wherein L2is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; its prodrug, their pharmaceutically acceptable salt, or solvate thereof.

Heterodimeric bis(amino thiol) complexes of oxorhenium(V) that mimic the structure of steroid hormones. Synthesis and stereochemical issues

We have prepared a series of bis-bidentate complexes of rhenium that mimic the size, shape, and peripheral functionality of steroidal androgens. In a model system, we used 2D NMR and X-ray crystallographic analysis to show that adjacent N-methyl and oxo substitutents adopt an anti configuration during the coordination reaction. We have synthesized a bis-bidentate oxorhenium(V) complex whose structure and peripheral functionality mimic 5α-dihydrotestosterone. 2D-NMR analysis indicates that the N-methyl and oxo substituents are driven into the steroidal anti configuration (β-N-methyl, α-oxo) by the β-orientation of the methyl group equivalent to C-18. Thus, this metal complex provides a remarkable structural and stereochemical mimic of a steroid. Its in vivo stability, however, appears to be limited.