5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine

Base Information

Chemical Name:5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine
CAS No.:176755-84-3
Molecular Formula:C₃₅H₃₉N₃O₇
Molecular Weight:613.711
Hs Code.:
DSSTox Substance ID:DTXSID601119371

Synonyms:176755-84-3;5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine;N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]-2-methylpropanamide;DTXSID601119371;N-(1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)isobutyramide;CID 15277142

Suppliers and Price of 5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:613.27880059
Heavy Atom Count:45
Complexity:1050

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CN(C(=O)N=C1NC(=O)C(C)C)C2CC(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O
Isomeric SMILES:CC1=CN(C(=O)N=C1NC(=O)C(C)C)[C@H]2C[C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

Technology Process of 5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine

There total 6 articles about 5'-O-(4,4'-Dimethoxytrityl)-N4-isobutyryl-5-methyl-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-trimethylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide

: 176755-84-3
N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide

Guidance literature:: With water; In methanol; Yield given;
DOI:10.1080/07328319608002137

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 176755-84-3
N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 6 steps

1: acetonitrile / 1 h / 55 °C

2: Et₃N / acetonitrile / 4 h / Ambient temperature

3: NH₃ / dioxane / 60 °C / overnight

4: pyridine / 1 h / Ambient temperature

5: pyridine / 3 h / Ambient temperature

6: H₂O / methanol

With pyridine; ammonia; water; triethylamine; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1080/07328319608002137

Reference yield:

: 117032-49-2
4-(1,2,4-triazol-1-yl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-trimethylsilyl thymidine

: 176755-84-3
N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: NH₃ / dioxane / 60 °C / overnight

2: pyridine / 1 h / Ambient temperature

3: pyridine / 3 h / Ambient temperature

4: H₂O / methanol

With pyridine; ammonia; water; In 1,4-dioxane; methanol;
DOI:10.1080/07328319608002137