[(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

Base Information

• Chemical Name: [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester
• CAS No.: 247017-98-7
• Molecular Formula: C₅₂H₄₈N₃O₉P
• Molecular Weight: 889.942
• Mol file: 247017-98-7.mol

Synonyms:

Chemical Property of [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

There total 4 articles about [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

silver dibenzylphosphate (50651-75-7) + [(R)-2-[1-(2-Iodomethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-97-6) → [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-98-7)

Guidance literature:

In toluene; Heating;

DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

2-Chloromethylbenzoyl chloride (42908-86-1) → [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-98-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KN(TMS)2 / tetrahydrofuran / -78 °C

1.2: 99 percent / tetrahydrofuran

2.1: 100 percent / NaI / acetone / Heating

3.1: 83 percent / toluene / Heating

With potassium hexamethylsilazane; sodium iodide; In tetrahydrofuran; acetone; toluene; 1.1: Metallation / 1.2: Acylation / 2.1: Iodination / 3.1: Substitution;

DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

PD 154075 (158991-23-2) → [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-98-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KN(TMS)2 / tetrahydrofuran / -78 °C

1.2: 99 percent / tetrahydrofuran

2.1: 100 percent / NaI / acetone / Heating

3.1: 83 percent / toluene / Heating

With potassium hexamethylsilazane; sodium iodide; In tetrahydrofuran; acetone; toluene; 1.1: Metallation / 1.2: Acylation / 2.1: Iodination / 3.1: Substitution;

DOI:10.1016/S0960-894X(00)00183-9

upstream raw materials:

silver dibenzylphosphate

[(R)-2-[1-(2-Iodomethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

2-Chloromethylbenzoyl chloride

PD 154075