((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol

Base Information

• Chemical Name: ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol
• CAS No.: 195727-73-2
• Molecular Formula: C₁₅H₂₃NO
• Molecular Weight: 233.354
• Mol file: 195727-73-2.mol

Synonyms:

Chemical Property of ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol

There total 5 articles about ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzoyl)-L-proline (5874-58-8) → ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol (195727-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃

2: 95 percent / Et₄NTs / anodic oxidation

3: CuBr*Me₂S, BF₃*Et₂O

4: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate; potassium carbonate; tetraethylammonium tosylate; In tetrahydrofuran;

DOI:10.1055/s-1997-5789

Reference yield:

1-Benzoyl-2-methoxy-5-(methoxycarbonyl)pyrrolidine (195727-70-9) → ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol (195727-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CuBr*Me₂S, BF₃*Et₂O

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate; In tetrahydrofuran;

DOI:10.1055/s-1997-5789

Reference yield:

benzoyl chloride (98-88-4) → ((2S,5R)-1-Benzyl-5-propyl-pyrrolidin-2-yl)-methanol (195727-73-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.25M NaOH

2: K₂CO₃

3: 95 percent / Et₄NTs / anodic oxidation

4: CuBr*Me₂S, BF₃*Et₂O

5: LiAlH₄ / tetrahydrofuran

With sodium hydroxide; lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate; potassium carbonate; tetraethylammonium tosylate; In tetrahydrofuran;

DOI:10.1055/s-1997-5789

upstream raw materials:

N-(benzoyl)-L-proline

1-Benzoyl-2-methoxy-5-(methoxycarbonyl)pyrrolidine

benzoyl chloride

N-benzoyl-L-proline methyl ester

Downstream raw materials:

(3R,6R)-1-Benzyl-6-propyl-piperidin-3-ol