1,8-Naphthyridine-3-carboxylic acid, 7-[3-(acetylamino)-1-pyrrolidinyl]-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro -4-oxo-, ethyl ester

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 7-[3-(acetylamino)-1-pyrrolidinyl]-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro -4-oxo-, ethyl ester
CAS No.:100491-97-2
Molecular Formula:C23H22F2N4O4
Molecular Weight:456.449
Hs Code.:
Mol file:100491-97-2.mol

Synonyms:

Suppliers and Price of 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(acetylamino)-1-pyrrolidinyl]-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro -4-oxo-, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(acetylamino)-1-pyrrolidinyl]-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro -4-oxo-, ethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(acetylamino)-1-pyrrolidinyl]-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro -4-oxo-, ethyl ester

There total 6 articles about 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(acetylamino)-1-pyrrolidinyl]-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro -4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 79286-74-1
3-acetylaminopyrrolidine

: 100491-30-3
ethyl 7-chloro-1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 100491-97-2
7-(3-Acetylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: With pyridine; for 3h; Ambient temperature;

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 100491-97-2
7-(3-Acetylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 2 h / 80 °C

2: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h

3: 1.) Ac₂O / 1.) 130 deg C, 1 h, 2.) CH₂Cl₂, RT, 0.5 h

4: 59.6 percent / NaH / tetrahydrofuran / 1 h / Heating

5: 88 percent / pyridine / 3 h / Ambient temperature

With pyridine; n-butyllithium; thionyl chloride; biquinoline; acetic anhydride; sodium hydride; In tetrahydrofuran;

Reference yield:

: 96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 100491-97-2
7-(3-Acetylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Ac₂O / 1.) 130 deg C, 1 h, 2.) CH₂Cl₂, RT, 0.5 h

2: 59.6 percent / NaH / tetrahydrofuran / 1 h / Heating

3: 88 percent / pyridine / 3 h / Ambient temperature

With pyridine; acetic anhydride; sodium hydride; In tetrahydrofuran;