(R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

Base Information

Chemical Name:(R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid
CAS No.:884345-40-8
Molecular Formula:C₄₁H₇₀O₁₀Si₂
Molecular Weight:779.172
Hs Code.:

(R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

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Suppliers and Price of (R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

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Chemical Property of (R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

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Technology Process of (R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

There total 11 articles about (R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyraldehyde

: 884345-40-8
(R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol;
DOI:10.1016/j.tetlet.2006.01.097

Reference yield:

: 884345-37-3
(3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-hydroxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxyheptadec-16-en-3-ol

: 884345-40-8
(R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / iPr₂NEt / CH₂Cl₂ / 20 °C

2: 85 percent / nBu₄NF / tetrahydrofuran / 20 °C

3: Dess-Martin periodinane

4: NaClO₂; NaH₂PO₄; 2-methylbut-2-ene / 2-methyl-propan-2-ol

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 3: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2006.01.097

Reference yield:

: 884345-36-2
(S)-4-Benzyloxy-1-{(2S,6R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-yl}-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,3-dimethyl-pentan-2-one

: 884345-40-8
(R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / PPTS / methanol

2: 79 percent / iPr₂NEt / CH₂Cl₂ / 20 °C

3: 85 percent / nBu₄NF / tetrahydrofuran / 20 °C

4: Dess-Martin periodinane

5: NaClO₂; NaH₂PO₄; 2-methylbut-2-ene / 2-methyl-propan-2-ol

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; 4: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2006.01.097