884345-36-2

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 807365-21-5 (S)-3-Benzyloxy-4-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2,2-dimethyl-butan-1-ol 
• 135413-38-6 (3S,5R,7S)-7-benzyloxy-1-tert-butyldiphenylsiloxy-9-(p-methoxyphenyl)methoxy-8,8-dimethylnonane-3,5-diol 
• 135304-57-3 (3S,5R,7S)-3-benzyloxy-9-tert-butyldiphenylsiloxy-1-(p-methoxyphenyl)methoxy-2,2-dimethyl-5,7-isopropylidenedioxynonane 
• 135304-56-2 (5S,7S)-7-benzyloxy-1-tert-butyldiphenylsiloxy-5-hydroxy-9-(p-methoxyphenyl)methoxy-8,8-dimethylnonan-3-one 
• 97250-25-4 tert-Butyldiphenylsilyl β-hydroxybutanone 
• 114079-44-6 1-O-(tert-butyl)diphenylsilyl-1,3-butanediol 
• 135304-55-1 (3S)-3-benzyloxy-5-(p-methoxyphenyl)methoxy-4,4-dimethylpentanal 
• 807364-88-1 (3S)-3-benzyloxy-4,4-dimethyl-5-(4-methoxybenzyloxy)pentan-1-ol 
• 807364-82-5 (3S)-3-benzyloxy-2,2-dimethyl-1-(4-methoxybenzyloxy)pent-4-ene 
• 147252-93-5 (3S)-3-(benzyloxy)-2,2-dimethyl-4-penten-1-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 807365-26-0 ((S)-4-Benzyloxy-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,3-dimethyl-2-oxo-pentyl)-phosphonic acid dimethyl ester 
• 884345-35-1 (S)-4-Benzyloxy-1-{(2S,6R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-eth-(Z)-ylidene]-6-hydroxymethyl-tetrahydro-pyran-2-yl}-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,3-dimethyl-pentan-2-one 

Downstream Products

• 884345-39-5 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-13-[(Z)-2-(2-trimethylsilylethoxymethoxy)ethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-3-(2-trimethylsilylethoxymethoxy)heptadec-16-en-1-ol 
• 884345-40-8 (R)-4-((2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-{(2S,6R)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid 
• 884345-38-4 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-(2-trimethylsilylethoxymethoxy)ethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-3-(2-trimethylsilylethoxymethoxy)heptadec-16-ene 
• 884345-37-3 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-hydroxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxyheptadec-16-en-3-ol 

Relevant academic research and scientific papers

The evolution of a stereoselective synthesis of the C1-C16 fragment of bryostatins

The development of a synthesis of the C1-C16 fragment of bryostatins in which the key step is a stereoselective oxy-Michael reaction used to assemble the cis-2,6-disubstituted tetrahydropyran with the exocyclic alkene already installed, is described. Foll

A preliminary evaluation of a metathesis approach to bryostatins

Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at C-18, did no