7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide

Base Information

• Chemical Name: 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide
• CAS No.: 915721-28-7
• Molecular Formula: C₂₁H₁₆FN₃O₃S₂
• Molecular Weight: 441.507
• Mol file: 915721-28-7.mol

Synonyms:

Chemical Property of 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide

There total 4 articles about 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-methylsulfanyl-phenylamino)-thiazole-4-carboxylic acid methyl ester (915720-86-4) → 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide (915721-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / Heating

2: NaOMe / methanol

3: 100 - 120 °C

With sodium methylate; In methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2006.08.007

Reference yield:

5-[methoxycarbonylacetyl-(3-methylsulfanyl-phenyl)-amino]-thiazole-4-carboxylic acid methyl ester (915720-95-5) → 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide (915721-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / methanol

2: 100 - 120 °C

With sodium methylate; In methanol;

DOI:10.1016/j.bmcl.2006.08.007

Reference yield:

1-isothiocyanato-3-methylsulfanylbenzene (51333-80-3) → 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide (915721-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1: t-BuOK / tetrahydrofuran

2: 1,2-dichloro-ethane / Heating

3: NaOMe / methanol

4: 100 - 120 °C

With potassium tert-butylate; sodium methylate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2006.08.007

upstream raw materials:

7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid methyl ester

para-fluorobenzylamine

5-(3-methylsulfanyl-phenylamino)-thiazole-4-carboxylic acid methyl ester

5-[methoxycarbonylacetyl-(3-methylsulfanyl-phenyl)-amino]-thiazole-4-carboxylic acid methyl ester