C₂₆H₂₄F₉N₃O₂

Base Information

• Chemical Name: C₂₆H₂₄F₉N₃O₂
• CAS No.: 874501-92-5
• Molecular Formula: C₂₆H₂₄F₉N₃O₂
• Molecular Weight: 581.481
• Mol file: 874501-92-5.mol

Synonyms:

Chemical Property of C₂₆H₂₄F₉N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₄F₉N₃O₂

There total 9 articles about C₂₆H₂₄F₉N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2R,4S]4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester (261947-57-3) + bromocyane (506-68-3) → C26H24F9N3O2 (874501-92-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

(2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester (474645-96-0) → C26H24F9N3O2 (874501-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr

3: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,1-dichloroethane; ethyl acetate;

DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

(R)-3-aminopentanenitrile methanesulfonic acid salt (474645-97-1) → C26H24F9N3O2 (874501-92-5)

Guidance literature:

Multi-step reaction with 8 steps

1: palladium diacetate; caesium carbonate; DavePhos; phenylboronic acid / dichloromethane; toluene / 80 °C

2: sulfuric acid / toluene / 35 °C

3: lithium tert-butoxide / tetrahydrofuran; diethyl ether / -10 - 0 °C

4: sodium tetrahydroborate; magnesium chloride / ethanol; water

5: pyridine / 0 - 20 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr

7: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 °C

8: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With pyridine; sodium tetrahydroborate; sodium tris(acetoxy)borohydride; sulfuric acid; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; magnesium chloride; lithium tert-butoxide; DavePhos; phenylboronic acid; In tetrahydrofuran; diethyl ether; 1,1-dichloroethane; ethanol; dichloromethane; water; ethyl acetate; toluene;

DOI:10.1016/j.bmcl.2012.04.042

upstream raw materials:

(2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester

[2R,4S]4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

bromocyane

(R)-3-aminopentanenitrile methanesulfonic acid salt

Downstream raw materials:

C₃₀H₃₁F₉N₆O₂

C₂₈H₂₆F₉N₇O₂

C₂₉H₂₈F₉N₇O₂

C₂₈H₂₈ClF₉N₆O₂