{1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

Base Information

• Chemical Name: {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester
• CAS No.: 1054824-55-3
• Molecular Formula: C₄₈H₅₄N₃O₁₂PSi
• Molecular Weight: 924.029

Synonyms:

Chemical Property of {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

Chemical Property:

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Useful:

Technology Process of {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

There total 5 articles about {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphanyloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (1053701-97-5) → {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (1054824-55-3)

Guidance literature:

With tert.-butylhydroperoxide; In 2,2,4-trimethylpentane; Yield given;

DOI:10.1021/jo951593c

Reference yield:

2-(3,5-dimethoxyphenyl)-2-hydroxy-1-phenylethan-1-one (34904-92-2) → {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (1054824-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / acetonitrile

2: t-BuOOH / 2,2,4-trimethyl-pentane

With 1H-tetrazole; tert.-butylhydroperoxide; In 2,2,4-trimethylpentane; acetonitrile;

DOI:10.1021/jo951593c

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → {1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (1054824-55-3)

Guidance literature:

Multi-step reaction with 4 steps

1: Py / 72 h

2: iPr₂EtN / CH₂Cl₂ / 1.5 h

3: 1H-tetrazole / acetonitrile

4: t-BuOOH / 2,2,4-trimethyl-pentane

With pyridine; 1H-tetrazole; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In 2,2,4-trimethylpentane; dichloromethane; acetonitrile;

DOI:10.1021/jo951593c

upstream raw materials:

{1-[(2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphanyloxy}-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

2-(3,5-dimethoxyphenyl)-2-hydroxy-1-phenylethan-1-one

tert-butylchlorodiphenylsilane

{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

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