{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

Base Information

Chemical Name:{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester
CAS No.:175354-92-4
Molecular Formula:C₂₉H₃₅N₃O₆Si
Molecular Weight:549.699
Hs Code.:

{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

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Chemical Property of {1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

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Technology Process of {1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

There total 1 articles about {1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102423-13-2
N⁴-[(allyloxy)carbonyl]-2'-deoxycytidine

: 58479-61-1
tert-butylchlorodiphenylsilane

: 175354-92-4
{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

: {1-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

Guidance literature:: With pyridine; for 72h; Yield given. Yields of byproduct given;
DOI:10.1021/jo951593c

Reference yield:

: 175354-92-4
{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

: [1-((2R,4S,5R)-4-{Allyloxy-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: iPr₂EtN / CH₂Cl₂ / 1.5 h

2: 1H-tetrazole / acetonitrile

3: t-BuOOH / 2,2,4-trimethyl-pentane

4: Et₃N*3HF / tetrahydrofuran

With 1H-tetrazole; tert.-butylhydroperoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2,2,4-trimethylpentane; dichloromethane; acetonitrile;
DOI:10.1021/jo951593c

Reference yield:

: 175354-92-4
{1-[(2R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

: [1-((2R,4S,5R)-4-{(2-Cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: iPr₂EtN / CH₂Cl₂ / 1.5 h

2: 1H-tetrazole / acetonitrile

3: t-BuOOH / 2,2,4-trimethyl-pentane

4: Et₃N*3HF / tetrahydrofuran

With 1H-tetrazole; tert.-butylhydroperoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2,2,4-trimethylpentane; dichloromethane; acetonitrile;
DOI:10.1021/jo951593c