Technology Process of (S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentanoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
There total 13 articles about (S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentanoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran
3.1: sodium hydroxide / ethanol
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C
4.2: 20 °C
5.1: hydroxylamine potassium salt / methanol / 1 h
5.2: pH 5 - 6
With
4-methyl-morpholine; hydrogenchloride; hydroxylamine potassium salt; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm200577a
- Guidance literature:
-
C32H43N3O7;
With
hydroxylamine potassium salt;
In
methanol;
for 1h;
With
hydrogenchloride;
In
water;
pH=5 - 6;
DOI:10.1021/jm200577a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran
2: trifluoroacetic acid / dichloromethane
3: hydroxylamine potassium salt / methanol
With
hydroxylamine potassium salt; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c3ra43249a
