(S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

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Chemical Name:(S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid
CAS No.:126542-02-7
Molecular Formula:C₃₁H₄₅F₃N₆O₉
Molecular Weight:702.728
Hs Code.:

(S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

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Chemical Property of (S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

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Technology Process of (S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

There total 9 articles about (S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126542-01-6
N-<3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl>-L-threonyl-D-valyl-L-prolyl-sarcosyl-(N-methyl-L-valin)-benzylester

: 126542-02-7
(S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

Guidance literature:: With hydrogen; A-Kohle; palladium; In methanol;

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 126542-02-7
(S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1: 25 percent / HNO₃ (d=1.5) / 1 h / Heating

2: 88 percent / H₂ / Pd/A-Kohle / methanol

3: 70 percent / NaNO₂, aq. H₂SO₄ / acetic acid / -5 deg C, 15 min, then room temp., 2h, then reflux, 3 min

4: 301 mg / N-Methylmorpholin, 1-Hydroxybenzotriazol, DCC / dimethylformamide; CH₂Cl₂ / 0 deg C, 2h, then room temp., 16h

5: 42 percent / HNO₃ (d=1.42) / acetic acid / 50 °C

6: 90 percent / aq. NaOH / acetone / 1 h / 22 °C

7: 480 mg / Triethylamin, 1-Hydroxybenzotriazol, DCC / CH₂Cl₂; dimethylformamide / 0 deg C, 2h, then RT, 16h

8: H₂ / Pd/A-Kohle / methanol

With 4-methyl-morpholine; sodium hydroxide; sulfuric acid; hydrogen; nitric acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium nitrite; A-Kohle; palladium; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

: 125483-00-3
3-amino-4-(trifluoromethyl)benzoic acid

: 126542-02-7
(S)-2-({2-[((S)-1-{(R)-2-[(2S,3R)-2-(2-Amino-3-hydroxy-4-trifluoromethyl-benzoylamino)-3-hydroxy-butyrylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / NaNO₂, aq. H₂SO₄ / acetic acid / -5 deg C, 15 min, then room temp., 2h, then reflux, 3 min

2: 301 mg / N-Methylmorpholin, 1-Hydroxybenzotriazol, DCC / dimethylformamide; CH₂Cl₂ / 0 deg C, 2h, then room temp., 16h

3: 42 percent / HNO₃ (d=1.42) / acetic acid / 50 °C

4: 90 percent / aq. NaOH / acetone / 1 h / 22 °C

5: 480 mg / Triethylamin, 1-Hydroxybenzotriazol, DCC / CH₂Cl₂; dimethylformamide / 0 deg C, 2h, then RT, 16h

6: H₂ / Pd/A-Kohle / methanol

With 4-methyl-morpholine; sodium hydroxide; sulfuric acid; hydrogen; nitric acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium nitrite; A-Kohle; palladium; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;