5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole

Base Information

• Chemical Name: 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole
• CAS No.: 113321-69-0
• Molecular Formula: C₃₀H₂₈N₆O₄S₂
• Molecular Weight: 600.722
• Mol file: 113321-69-0.mol

Synonyms:

Chemical Property of 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole

There total 7 articles about 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7,7'-diamino-5,5'-dimethyl-2,2'-biindazole (113302-80-0) + p-toluenesulfonyl chloride (98-59-9) → 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole (113321-69-0)

Guidance literature:

With pyridine; for 16h; Ambient temperature;

DOI:10.1021/jo00244a038

Reference yield:

2-hydroxy-5-methyl-3-nitro-benzaldehyde (66620-31-3) → 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole (113321-69-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 2 h / 90 °C

2: sodium azide / H₂O / 10 h / Ambient temperature

3: 93 percent / hydrazine hydrate, HCl / ethanol / Heating

4: 90 percent / various solvent(s) / 2 h / 150 °C

5: 70 percent / H₂ / 10percent Pd/C / ethyl acetate / 20 h / Heating

6: 100 percent / pyridine / 16 h / Ambient temperature

With pyridine; hydrogenchloride; sodium azide; hydrogen; hydrazine hydrate; palladium on activated charcoal; In ethanol; water; ethyl acetate;

DOI:10.1021/jo00244a038

Reference yield:

2-hydroxy-5-methylbenzaldehyde (613-84-3) → 5,5'-dimethyl-7,7'-bis(p-toluenesulfonamido)-2,2'-biindazole (113321-69-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 65 percent / fuming nitric acid / 0 °C

2: 2 h / 90 °C

3: sodium azide / H₂O / 10 h / Ambient temperature

4: 93 percent / hydrazine hydrate, HCl / ethanol / Heating

5: 90 percent / various solvent(s) / 2 h / 150 °C

6: 70 percent / H₂ / 10percent Pd/C / ethyl acetate / 20 h / Heating

7: 100 percent / pyridine / 16 h / Ambient temperature

With pyridine; hydrogenchloride; sodium azide; hydrogen; nitric acid; hydrazine hydrate; palladium on activated charcoal; In ethanol; water; ethyl acetate;

DOI:10.1021/jo00244a038

upstream raw materials:

7,7'-diamino-5,5'-dimethyl-2,2'-biindazole

p-toluenesulfonyl chloride

2-hydroxy-5-methyl-3-nitro-benzaldehyde

2-hydroxy-5-methylbenzaldehyde

Downstream raw materials:

7-amino-5-methylindazole

5,5'-dimethyl-7,7'-bis-2,2'-biindazole