<<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate

Base Information

Chemical Name:<<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate
CAS No.:111025-97-9
Molecular Formula:C₃₂H₄₃NO₃
Molecular Weight:489.698
Hs Code.:

<<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benz<f>inden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate

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Technology Process of <<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate

There total 16 articles about <<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 75-44-5
phosgene

: 2627-86-3
(S)-1-phenyl-ethylamine

: 101691-75-2,111138-81-9,111186-52-8
(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-2H-benzinden-2-ol

: 111025-97-9,111025-98-0
<<1(S)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aR,9aR)-benzinden-2(S)-yl>oxy>-(S)-α-methylbenzyl carbamate

: 111025-97-9,111025-98-0
<<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate

Guidance literature:: With triethylamine; In toluene; for 0.416667h;
DOI:10.1021/jo00234a016

Reference yield: 40.0%

: 75-44-5
phosgene

: 2627-86-3
(S)-1-phenyl-ethylamine

: 101691-75-2,111138-81-9,111186-52-8
(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-2H-benzinden-2-ol

: 111025-97-9,111025-98-0
<<1(S)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aR,9aR)-benzinden-2(S)-yl>oxy>-(S)-α-methylbenzyl carbamate

: 111025-97-9,111025-98-0
<<1(R)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aS,9aS)-benzinden-2(R)-yl>oxy>-(S)-α-methylbenzyl carbamate

Guidance literature:: With triethylamine; In toluene; for 0.416667h;
DOI:10.1021/jo00234a016

Reference yield:

: 60439-16-9
1-bromo-4-cyclohexylbutane

: 111025-97-9,111025-98-0
<<1(S)-(cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1H-(3aR,9aR)-benzinden-2(S)-yl>oxy>-(S)-α-methylbenzyl carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / n-butyllithium / tetrahydrofuran; hexane / 5 h / 20 - 60 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C to 0 deg C, 3 h

3: H₂ / 10percent Pd/C / ethanol / 46 h / 2585.7 Torr / Ambient temperature

4: 93 percent / aq. sodium hydride, sodium borohydride / ethanol; CH₂Cl₂ / 2 h / -10 °C

5: 33.5 percent / triethylamine / toluene / 0.42 h

With sodium tetrahydroborate; n-butyllithium; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene;
DOI:10.1021/jo00234a016