5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

Base Information

Chemical Name:5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol
CAS No.:135755-09-8
Molecular Formula:C₃₅H₄₆N₂O₇SSi
Molecular Weight:666.911
Hs Code.:

5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

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Chemical Property of 5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

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Technology Process of 5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

There total 7 articles about 5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 135755-08-7,135755-12-3
5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-D-erythro-D/L-glycero-pentitol

: 135755-09-8,135755-13-4
5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

Guidance literature:: With pyridine; for 24h; Ambient temperature;
DOI:10.1002/hlca.19920750516

Reference yield:

: 108866-75-7
2-deoxy-D-ribose dipropyl dithioacetal

: 135755-09-8,135755-13-4
5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

2: 81 percent / TsOH / 12 h / Ambient temperature

3: 53 percent / HgO, HgCl₂ / acetone; H₂O / 5 h / Heating

4: tetrahydrofuran; hexane / 2 h / -78 °C

5: 90 percent / pyridine / 24 h / Ambient temperature

With pyridine; 1H-imidazole; toluene-4-sulfonic acid; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/hlca.19920750516

Reference yield:

: 452-51-7,13046-70-3,29780-54-9,36792-87-7,36792-88-8,113890-35-0,113890-38-3
D-2-deoxyribose

: 135755-09-8,135755-13-4
5-O-<(tert-butyl)diphenylsilyl>-2-deoxy-1-C-<4-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridin-2-yl>-3,4-O-isopropylidene-1-O-(methylsulfonyl)-D-erythro-D/L-glycero-pentitol

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / 10 M HCl / 0.33 h / 10 °C

2: 82 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

3: 81 percent / TsOH / 12 h / Ambient temperature

4: 53 percent / HgO, HgCl₂ / acetone; H₂O / 5 h / Heating

5: tetrahydrofuran; hexane / 2 h / -78 °C

6: 90 percent / pyridine / 24 h / Ambient temperature

With pyridine; 1H-imidazole; hydrogenchloride; toluene-4-sulfonic acid; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/hlca.19920750516