Technology Process of (1aR,2R,3S,13cS)-1a,2,3,13c-tetrahydrobenzo[c][1]benzoxireno[2,3-h]acridine-2,3-diol
There total 9 articles about (1aR,2R,3S,13cS)-1a,2,3,13c-tetrahydrobenzo[c][1]benzoxireno[2,3-h]acridine-2,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran;
for 3h;
Ambient temperature;
DOI:10.1021/jo00201a019
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 12.9 percent / 0.25 h / 250 °C
3: 88 percent / 25percent aq. NaOH / tetrahydrofuran; methanol / 5 h / Ambient temperature
4: 92 percent / pyridine / 24 h / Ambient temperature
5: 96 percent / NBS, AIBN / CCl4 / 0.25 h / 60 - 62 °C
6: 66 percent / Li2CO3, LiF / hexamethylphosphoric acid triamide / 3 h / 85 - 90 °C
7: 93 percent / NH3 / methanol; tetrahydrofuran / 4 h / Ambient temperature
8: 70 percent / m-chloroperbenzoic acid / tetrahydrofuran / 3 h / Ambient temperature
With
pyridine; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; lithium carbonate; lithium fluoride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00201a019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / pyridine / 24 h / Ambient temperature
2: 96 percent / NBS, AIBN / CCl4 / 0.25 h / 60 - 62 °C
3: 66 percent / Li2CO3, LiF / hexamethylphosphoric acid triamide / 3 h / 85 - 90 °C
4: 93 percent / NH3 / methanol; tetrahydrofuran / 4 h / Ambient temperature
5: 70 percent / m-chloroperbenzoic acid / tetrahydrofuran / 3 h / Ambient temperature
With
pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; lithium carbonate; lithium fluoride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00201a019