4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid

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Chemical Name:4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid
CAS No.:1328994-76-8
Molecular Formula:C₂₉H₂₄F₂N₂O₈S₂
Molecular Weight:630.647
Hs Code.:

Synonyms:

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Chemical Property of 4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid

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Technology Process of 4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid

There total 8 articles about 4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoate

: 1328994-76-8,1328994-77-9,1328986-21-5
4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 1328997-84-7
2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetic acid

: 1328994-76-8,1328994-77-9,1328986-21-5
4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C / Inert atmosphere

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 39161-84-7
4-mercaptophenylacetic acid

: 1328994-76-8,1328994-77-9,1328986-21-5
4-[2-[[2-(2,4-difluorophenoxy)-2-(4-tetrahydropyran-4-ylsulfonylphenyl)acetyl]amino]thiazol-5-yl]oxybenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / methanol / 24 h / 20 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / Inert atmosphere

4.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux; Inert atmosphere

5.1: potassium carbonate / acetonitrile / 14 h / 20 - 25 °C / Inert atmosphere

6.1: lithium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C / Inert atmosphere

7.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

7.2: 2 h / 20 °C / Inert atmosphere

8.1: lithium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042