C₂₇H₂₇ClF₂N₂O

Base Information

Chemical Name:C₂₇H₂₇ClF₂N₂O
CAS No.:1366037-97-9
Molecular Formula:C₂₇H₂₇ClF₂N₂O
Molecular Weight:468.974
Hs Code.:

C<sub>27</sub>H<sub>27</sub>ClF<sub>2</sub>N<sub>2</sub>O

Synonyms:

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Chemical Property of C₂₇H₂₇ClF₂N₂O

Chemical Property:

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Technology Process of C₂₇H₂₇ClF₂N₂O

There total 7 articles about C₂₇H₂₇ClF₂N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67197-54-0
2-(4-bromo-2-chlorophenyl)acetonitrile

: 1366037-97-9
C₂₇H₂₇ClF₂N₂O

Guidance literature:: Multi-step reaction with 8 steps

1: sodium ethanolate / ethanol

2: sulfuric acid; acetic acid

3: dimethylsulfide borane complex / tetrahydrofuran

4: N-ethyl-N,N-diisopropylamine / dichloromethane

5: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol

6: palladium on activated charcoal; hydrogen / methanol

7: N-ethyl-N,N-diisopropylamine / dichloromethane

8: hydrogenchloride / 1,4-dioxane; dichloromethane

With hydrogenchloride; dimethylsulfide borane complex; sulfuric acid; palladium on activated charcoal; hydrogen; sodium ethanolate; palladium diacetate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol; ethanol; dichloromethane; 1: Michael addition / 5: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.044

Reference yield:

: C₁₇H₁₁BrClF₂NO₂

: 1366037-97-9
C₂₇H₂₇ClF₂N₂O

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylsulfide borane complex / tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol

4: palladium on activated charcoal; hydrogen / methanol

5: N-ethyl-N,N-diisopropylamine / dichloromethane

6: hydrogenchloride / 1,4-dioxane; dichloromethane

With hydrogenchloride; dimethylsulfide borane complex; palladium on activated charcoal; hydrogen; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol; dichloromethane; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.044

Reference yield:

: C₁₇H₁₅BrClF₂N

: 1366037-97-9
C₂₇H₂₇ClF₂N₂O

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol

3: palladium on activated charcoal; hydrogen / methanol

4: N-ethyl-N,N-diisopropylamine / dichloromethane

5: hydrogenchloride / 1,4-dioxane; dichloromethane

With hydrogenchloride; palladium on activated charcoal; hydrogen; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In 1,4-dioxane; methanol; propan-1-ol; dichloromethane; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.044