67197-54-0

Basic information

• Product Name: (4-BROMO-2-CHLOROPHENYL)ACETONOTRILE
• Synonyms: (4-BROMO-2-CHLOROPHENYL)ACETONOTRILE;2-(4-bromo-2-chlorophenyl)acetonitrile;4-bromo-2-(trifluoromethoxy)phenylacetonitrile;4-bromo-2-chlorophenylacetonitrile
• CAS NO: 67197-54-0
• Molecular Formula: C₈H₅BrClN
• Molecular Weight: 230.489
• EINECS: -0
• Mol File: 67197-54-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 315.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.603±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-BROMO-2-CHLOROPHENYL)ACETONOTRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-2-CHLOROPHENYL)ACETONOTRILE(67197-54-0)
• EPA Substance Registry System: (4-BROMO-2-CHLOROPHENYL)ACETONOTRILE(67197-54-0)

Safety Data

• Hazardous Substances Data: 67197-54-0(Hazardous Substances Data)

Usage

General Description

(4-Bromo-2-chlorophenyl)acetonitrile is a chemical compound with the molecular formula C8H6BrClN. It is a nitrile compound, which means it contains a carbon triple-bonded to a nitrogen atom. (4-BROMO-2-CHLOROPHENYL)ACETONOTRILE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It is also used in the production of dyes and pigments. (4-Bromo-2-chlorophenyl)acetonitrile is a colorless to pale yellow liquid with a pleasant odor. It should be handled with care, as it is toxic if swallowed, inhaled, or absorbed through the skin. The compound should be stored in a well-ventilated area and kept away from direct sunlight and heat sources.

Upstream product

• 916516-89-7 2-(4-bromo-2-chlorophenyl)acetic acid 
• 773837-37-9 sodium cyanide 
• 89720-77-4 4-bromo-1-bromomethyl-2-chlorobenzene 
• 89794-02-5 4-bromo-2-chlorotoluene 
• 185315-48-4 (4-bromo-2-chlorophenyl)methanol 
• 59748-90-2 4-Bromo-2-chloro-benzoic Acid 
• 151-50-8 potassium cyanide 

Downstream Products

• 849934-94-7 methyl 2-(4-bromo-2-chlorophenyl)acetate 
• 1428758-45-5 C₂₉H₂₉ClN₈O 
• 1330065-78-5 C₃₀H₃₀ClN₇OS 
• 1428760-83-1 3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)benzonitrile 
• 1428759-01-6 C₂₇H₂₇ClN₁₀O 
• 1428760-84-2 3-chloro-4-(8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-hydroxybenzimidamide 
• 1428760-85-3 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]benzonitrile 
• 1428760-86-4 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide 
• 1428760-87-5 6-[2-chloro-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-8-ethyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1261606-45-4 (4-bromo-2-chlorophenyl)acetic acid ethyl ester 
• 1428760-88-6 6-[2-chloro-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-8-ethyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1428759-09-4 6-[2-chloro-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazino)anilino]pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1428759-13-0 C₂₈H₂₆ClN₇O₂ 
• 1428760-89-7 6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant articles and documents

HETEROCYCLIC FXR MODULATORS

The present technology is directed to compounds of formula (I), compositions, and methods related to modulation of FXR. In particular, the present compounds and compositions may be used to treat FXR-mediated disorders and conditions, including, e.g., liver disease, hyperlipidemia, hypercholesteremia, obesity, metabolic syndrome, cardiovascular disease, gastrointestinal disease, and atherosclerosis, and renal disease.

SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, Re, n, r, s and t are as defined herein and which compounds are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.

2- PYRIDONE COMPOUND

PROBLEM TO BE SOLVED: To provide a compound that has excellent glucokinase (GK) activating action and is useful as a pharmaceutical. SOLUTION: The present invention provides a 2-pyridone compound represented by formula [1], and a tautomer or stereoisomer of the compound, or their pharmacologically acceptable salts, or their solvates (where R1 is RA-ZA-; RA is any of a carboxy group, a sulfo group or formula [5]). COPYRIGHT: (C)2016,JPOandINPIT