Technology Process of (Z)-methyl 2-methyl-3-(3-methyl-1H-indol-2-yl)-3-[4-(trifluoromethyl)phenyl]acrylate
There total 7 articles about (Z)-methyl 2-methyl-3-(3-methyl-1H-indol-2-yl)-3-[4-(trifluoromethyl)phenyl]acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium proprionate / 12 h / 150 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide
3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
4.1: pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid / 1,3,5-trimethyl-benzene / 110 °C
5.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 20 °C / Inert atmosphere
6.1: methanol; diethyl ether / 20 °C / Inert atmosphere
With
pyridine-3-carbonitrile; oxalyl dichloride; sodium proprionate; oxygen; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; N,N-dimethyl-formamide; sodium hydroxide; Trimethylacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; 1,3,5-trimethyl-benzene;
1.1: Perkin reaction;
DOI:10.1002/anie.201106927
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid / 1,3,5-trimethyl-benzene / 110 °C
3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 20 °C / Inert atmosphere
4.1: methanol; diethyl ether / 20 °C / Inert atmosphere
With
pyridine-3-carbonitrile; oxygen; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; sodium hydroxide; Trimethylacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; 1,3,5-trimethyl-benzene;
DOI:10.1002/anie.201106927
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide
2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid / 1,3,5-trimethyl-benzene / 110 °C
4.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 20 °C / Inert atmosphere
5.1: methanol; diethyl ether / 20 °C / Inert atmosphere
With
pyridine-3-carbonitrile; oxalyl dichloride; oxygen; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; N,N-dimethyl-formamide; sodium hydroxide; Trimethylacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; 1,3,5-trimethyl-benzene;
DOI:10.1002/anie.201106927
