(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

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Chemical Name:(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid
CAS No.:1380111-25-0
Molecular Formula:C₂₅H₂₆N₈O₁₂S₂
Molecular Weight:694.66
Hs Code.:

(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

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Chemical Property of (2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

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Technology Process of (2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

There total 22 articles about (2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1380111-25-0
(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 13 steps

1: sodium hydroxide / methanol; water / 0.17 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 60 °C

3: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

5: potassium iodide / N,N-dimethyl-formamide / 20 °C

6: hydrazine hydrate / ethanol / 1 h / Reflux

7: ethyl acetate / 2 h / 50 °C

8: potassium phosphate / dichloromethane; water / 1 h / 22 °C

9: potassium phosphate; dipotassium peroxodisulfate / acetonitrile; water / 1.5 h / 75 °C

10: trifluoroacetic acid / 3 h / 0 °C

11: triethylamine / acetonitrile / 40 h / 20 °C

12: sulfur trioxide pyridine complex / N,N-dimethyl-formamide / 20 °C

13: boron trichloride / dichloromethane; para-xylene

With potassium phosphate; dipotassium peroxodisulfate; hydroxylamine hydrochloride; sodium acetate; sulfur trioxide pyridine complex; boron trichloride; potassium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; In methanol; ethanol; dichloromethane; para-xylene; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400560z

Reference yield:

: benzyl (2S)-2-(aminooxy)-4-methylpentanoate

: 1380111-25-0
(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 20 °C

2: dicyclohexyl-carbodiimide / dichloromethane / 20 °C

3: triethylamine / acetonitrile / 40 h / 20 °C

4: sulfur trioxide pyridine complex / N,N-dimethyl-formamide / 20 °C

5: boron trichloride / dichloromethane; para-xylene

With sulfur trioxide pyridine complex; boron trichloride; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; para-xylene; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400560z

Reference yield:

: C₂₆H₂₇N₃O₇S

: 1380111-25-0
(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2: triethylamine / acetonitrile / 40 h / 20 °C

3: sulfur trioxide pyridine complex / N,N-dimethyl-formamide / 20 °C

4: boron trichloride / dichloromethane; para-xylene

With sulfur trioxide pyridine complex; boron trichloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; para-xylene; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400560z