5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one

Base Information

• Chemical Name: 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one
• CAS No.: 1380109-77-2
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Mol file: 1380109-77-2.mol

Synonyms:5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one

Chemical Property of 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one

There total 4 articles about 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.3%

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one (15771-06-9) → 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one (1380109-77-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; at 60 ℃;

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one (1380109-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 0.17 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 60 °C

With hydroxylamine hydrochloride; sodium acetate; sodium hydroxide; In methanol; ethanol; water;

DOI:10.1021/jm400560z

Reference yield:

benzyl bromide (100-39-0) → 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one (1380109-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 0.17 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 60 °C

With hydroxylamine hydrochloride; sodium acetate; sodium hydroxide; In methanol; ethanol; water;

DOI:10.1021/jm400560z

upstream raw materials:

benzyl bromide

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one

benzyl chloride

Downstream raw materials:

C₄₈H₅₂N₈O₁₁S

C₄₇H₅₀N₈O₁₁S

(2S)-2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-su1foazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)-3-phenylpropanoic acid

C₄₁H₄₈N₈O₁₁S