Technology Process of (2S,5R)-2-ethyl-5-phenylpyrrolidine
There total 7 articles about (2S,5R)-2-ethyl-5-phenylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
borane-ammonia complex;
In
dimethyl sulfoxide;
at 30 ℃;
pH=7.5;
Reagent/catalyst;
diastereoselective reaction;
Enzymatic reaction;
DOI:10.1002/anie.201309208
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 24 h / Reflux
2: pyridoxal 5'-phosphate; nicotinamide adenine dinucleotide; D-Glucose; glucose dehydrogenase; lactate dehydrogenase; L-alanin; pseudogulbenkiania ferrooxidans transaminase / dimethyl sulfoxide / 48 h / 30 °C / pH 7.5 / Enzymatic reaction
3: borane-ammonia complex / dimethyl sulfoxide / 30 °C / pH 7.5 / Enzymatic reaction
With
glucose dehydrogenase; bis-triphenylphosphine-palladium(II) chloride; borane-ammonia complex; D-Glucose; L-alanin; pyridoxal 5'-phosphate; pseudogulbenkiania ferrooxidans transaminase; nicotinamide adenine dinucleotide; lactate dehydrogenase;
In
tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/anie.201309208
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 24 h / Reflux
2: pyridoxal 5'-phosphate; nicotinamide adenine dinucleotide; D-Glucose; glucose dehydrogenase; lactate dehydrogenase; L-alanin; pseudogulbenkiania ferrooxidans transaminase / dimethyl sulfoxide / 48 h / 30 °C / pH 7.5 / Enzymatic reaction
3: borane-ammonia complex / dimethyl sulfoxide / 30 °C / pH 7.5 / Enzymatic reaction
With
glucose dehydrogenase; bis-triphenylphosphine-palladium(II) chloride; borane-ammonia complex; D-Glucose; L-alanin; pyridoxal 5'-phosphate; pseudogulbenkiania ferrooxidans transaminase; nicotinamide adenine dinucleotide; lactate dehydrogenase;
In
tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/anie.201309208
