cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

Base Information

Chemical Name:cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole
CAS No.:147201-37-4
Molecular Formula:C₂₁H₂₅NO
Molecular Weight:307.436
Hs Code.:

cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benz<e>indole

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

Chemical Property:

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Technology Process of cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

There total 4 articles about cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.6%

: cis/trans-(+/-)-1,3,3a,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-2H-benzindol-2-one

: 147201-37-4
cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

: 147253-57-4
cis-2,3,3aS,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm00060a014

Reference yield:

: 5309-19-3
8-methoxy-2-tetralone

: 147201-37-4
cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, cyclohexane, -30 deg C, 30 min, 2.) THF, cyclohexane, RT, 2 h

2: 1.) acetic acid, 2.) sodium cyanoborohydride / 1.) MeOH, THF, from 0 deg C to 5 deg C, 30 min, 2.) MeOH, THF, RT

3: 41.1 percent / lithium aluminum hydride / tetrahydrofuran / 4 h / Heating

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jm00060a014

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 147201-37-4
cis-2,3,3aR,4,5,9b-hexahydro-9-methoxy-3-(2(R)-methylbenzyl)-1H-benzindole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic acid, 2.) sodium cyanoborohydride / 1.) MeOH, THF, from 0 deg C to 5 deg C, 30 min, 2.) MeOH, THF, RT

2: 41.1 percent / lithium aluminum hydride / tetrahydrofuran / 4 h / Heating

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm00060a014