5309-19-3

Usage

Uses

8-methoxy-3,4-dihydronaphthalen-2(1h)-one is a useful research chemical.

InChI:InChI=1/C11H12O2/c1-13-11-4-2-3-8-5-6-9(12)7-10(8)11/h2-4H,5-7H2,1H3

Upstream product

• 5309-18-2 1,7-dimethoxynaphthalene 
• 90266-08-3 8-Methoxy-3,8a-dihydroazulen-1(2H)-one 
• 90266-01-6 1-diazo-4-(2'-methoxyphenyl)butan-2-one 
• 20965-38-2 spiro<(1,3-dioxocyclopentane)-2,2'-(8'-methoxy-1',2',3',4'-tetrahydronaphthalene)> 
• 55116-09-1 2-bromophenylacetyl chloride 
• 575-38-2 1,7-Dihydroxynaphthalene 
• 22955-75-5 3-(2-methoxyphenyl)propionyl chloride 
• 135-02-4 ortho-anisaldehyde 
• 6099-04-3 trans-3-methoxycinnamic acid 
• 2450-71-7 Propargylamine 
• 497-19-8 sodium carbonate 
• 843652-67-5 1,7-dimethoxynaphthalen-2(1H)-one 
• 73706-63-5 1-Diazo-4-(3-methoxyphenyl)butan-2-one 
• 40478-49-7 3-(3-methoxyphenyl)propanoyl chloride 

Downstream Products

• 3902-22-5 8-methoxy-2-(propylamino)-1,2,3,4-tetrahydronaphthalene 
• 3897-94-7 8-methoxy-2-(di-n-propylamino)tetralin 
• 117145-83-2 (8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl-phenethyl-amine 
• 81185-19-5 N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine 
• 103392-93-4 methyl-(7-phenyl-[1]naphthyl)-ether 
• 80270-68-4 N-(1,2,3,4-tetrahydro,8-methoxy-2-naphthalenyl)-acetamide 
• 87394-71-6 8-methoxy-2-propylaminotetralin hydrochloride 
• 1374428-95-1 (S)-1,2,3,4-tetrahydronaphthalene-2,8-diyl bis(4-bromobenzoate) 
• 1374429-01-2 (S)-((S)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl) 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate 
• 53568-05-1 8-hydroxy-2-tetralone 
• 153221-21-7 (S)-N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 
• 153221-21-7 N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 
• 1347548-67-7 rac-methyl 4-{[(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}benzoate 
• 81185-23-1 S-(-)-8-methoxy-2-(n-propylamino)tetralin 

Relevant academic research and scientific papers

Synthesis and antifungal activities of novel 2-aminotetralin derivatives

Novel 2-aminotetralin derivatives were synthesized as antifungal agents. The 2-aminotetralin scaffold was chemically designed to mimic the tetrahydroisoquinoline ring of the lead molecule described before. Their antifungal activities were evaluated in vitro by measuring the minimal inhibitory concentrations (MICs). Compounds 10a, 12a, 12c, 13b, and 13d are more potent than fluconazole against seven testing human fungal pathogens. Compound 10b exhibits much higher antifungal activities against all of the four fluconazole-resistant clinic Candida albicans strains than the control drugs including amphotericin B, terbinafine, ketoconazole, and itraconazole. The mode of action of some compounds to the potential receptor lanosterol 14α-demethylase (CYP51) was investigated by molecular docking. The studies presented here provide a new structural type for the development of novel antifungal compounds. Furthermore, 10b was evaluated in vivo by a rat vaginal candidiasis model, and it was found that 10b significantly decreases the number of fungal colony counts.

3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES

3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.

AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF

The invention relates to aminotetralin derivatives of the formula I: wherein: R1 is methyl or ethyl; R2 is hydrogen, halogen, lower-alkoxy or thiolower-alkyl; R3 is hydrogen, halogen, lower-alkoxy or lower-alkyl; and the chiral center * is in the

A chemoenzymatic synthesis of (2R)-8-substituted-2-aminotetralins

(2R)-2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalene, a useful precursor of the 5-hydroxytryptamine receptor agonist 8-OH-DPAT ((2R)-2-(dipropylamino)-8-hydroxytetrahydronaphthalene), has been synthesized from 1-methoxynaphthalene through a chemoenzymatic protocol. The same protocol has been subsequently applied to the synthesis of other (2R)-2-amino-1,2,3,4-tetrahydronaphthalenes.

Aminotetralin derivative and compositions and method of use thereof

The invention relates to aminotetralin derivatives of the formula I: STR1 wherein: R1 is methyl or ethyl; R2 is hydrogen, halogen, lower-alkoxy or thiolower-alkyl; R3 is hydrogen, halogen, lower-alkoxy or lower-alkyl; and

DOPAMINE D-3 AND SEROTONIN (5-HT1A) RECEPTOR LIGANDS AND IMAGING AGENTS

Tetralin derivatives, such as 7-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)-amino]tetralin and 8-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)amino-tetralin, are disclosed which have affinity and specificity for dopamine D-3 and/or serotonin 5-HT 1A receptors.

Baker's Yeast Mediated Reduction of Aromatic Ring Substituted 2-Tetralones

2-Tetralones mono- and disubstituted with methoxy or hydroxy groups in the aromatic ring are hydrogenated to 2-tetralols in good yields by non-fermenting baker's yeast.The prevalent enantioform of the reduction product and its e.e. were found to depend on the substitution pattern.In one case, i.e. the biotransformation of 5-methoxy-2-tetralone into the corresponding 2-tetralol, an e.e. >/= 98percent was observed.A simple abstract model for explaining and predicting the stereochemical outcome in the yeast-mediated carbonyl reduction of 2-tetralones is proposed.

A new, simple procedure for the preparation of 8-methoxy-2-tetralone

8-Methoxy-2-tetralone (6) can be easily prepared in approximately 50% overall yield starting from 2-bromophenylacetic acid (1), utilizing a Friedel-Crafts acylation/cyclization, ketone protection, copper(I)-catalyzed methoxylation of the aromatic bromide

2-Amido-8-methoxytetralins: A Series of Nonindolic Melatonin-like Agents

A series of unsubstituted and methoxy-substituted 2-amidotetralins (4a-q) was prepared and evaluated for their ability to complete for 2-iodomelatonin binding to chicken retinal membranes and for their potency to inhibit the calcium-dependent release of dopamine from rabbit retina.The lead compound, 2-acetamido-8-methoxytetralin (4j), showed a moderate affinity (Ki = 46 nM) and potency (IC50 = 1.4 nM) at the melatonin receptor.The structural requirements necessary for optimal agonistic activity at the melatonin receptor are as follows.First, the amido group, which should have a small, nonbranched alkyl group, is essential for affinity, and second, the methoxy substituent at the 8-position of the 2-amidotetralin ring is essential for optimal agonistic activity at the melatonin receptor.We concluded that this series of unsubstituted and methoxy-substituted 2-amidotetralins constitutes a class of nonindolic melatonin-like agents that can be used as pharmacological tools to further characterize melatonin receptors and to elucidate the mode of action of melatonin.