(2-Methoxyphenyl)azanium;chloride

Base Information

• Chemical Name: (2-Methoxyphenyl)azanium;chloride
• CAS No.: 134-29-2
• Molecular Formula: C7H9 N O . Cl H
• Molecular Weight: 159.615
• Hs Code.: 2922299090
• Mol file: 134-29-2.mol

Synonyms:(2-methoxyphenyl)azanium;chloride

Chemical Property of (2-Methoxyphenyl)azanium;chloride

Chemical Property:

• Vapor Pressure: 0.0885mmHg at 25°C
• Melting Point: 228-230 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 35.25000
• Density: g/cm³
• LogP: 2.66060
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.0450916
• Heavy Atom Count: 10
• Complexity: 85

Purity/Quality:

97% ^*data from raw suppliers

o-Anisidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1[NH3+].[Cl-]
• Uses: o-Anisidine hydrochloride is used as a chemical intermediate in the production of numerous azo and triphenylmethane dyes and pigments (e.g., C.I. direct red 72, disperse orange 29, direct yellow 44, direct red 24, and acid red 4); in the production of pharmaceuticals, including the expectorant guaiacol; as a corrosion inhibitor for steel; and as an antioxidant for polymercaptan resins (IARC 1999, HSDB 2009).

Technology Process of (2-Methoxyphenyl)azanium;chloride

There total 7 articles about (2-Methoxyphenyl)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dimeric N-(o-methoxyphenyl)-As,As,As-triphenylarsine imide hydrochloride → triphenylarsineoxide (1153-05-5,856568-31-5) + 2-methoxyaniline hydrochloride (134-29-2) + hydroxytriphenylarsonium chloride

Guidance literature:

With water; for 2h; Product distribution; Heating; different reaction conditions of hydrolysis;

Reference yield: 70.0%

2-methoxyacetanilide (93-26-5) + ethylmagnesium bromide (925-90-6) → 2-methoxyaniline hydrochloride (134-29-2)

Guidance literature:

2-methoxyacetanilide; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 0.5h;

ethylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; dichloromethane; at -78 ℃; for 2h;

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.cclet.2015.05.033

Reference yield:

(2-methoxy-phenyl)-(4,4,5,5-tetramethyl-[1,3]dioxolan-2-ylidene)-amine → 2-methoxyaniline hydrochloride (134-29-2)

Guidance literature:

With hydrogenchloride; methanol; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/ol0479951

upstream raw materials:

2-Nitroanisole

2-methoxy-phenylamine

formic acid o-anisidide

2-methoxyacetanilide

Downstream raw materials:

1-(2-methoxyphenyl)guanidine

1-(2-methoxy-phenyl)-biguanide

5-o-Anisidino-2.2-dimethyl-3-pentanon

1-(2-methoxyphenyl)-3-phenoxycarbonylthiourea