Chalcone, .beta.-phenyl-

Base Information

• Chemical Name: Chalcone, .beta.-phenyl-
• CAS No.: 849-01-4
• Molecular Formula: C21H16 O
• Molecular Weight: 284.357
• Mol file: 849-01-4.mol

Synonyms:Acrylophenone,3,3-diphenyl- (6CI,7CI,8CI); 1,3,3-Triphenyl-2-propen-1-one; NSC 10420; NSC53394; b-Phenylchalcone

Chemical Property of Chalcone, .beta.-phenyl-

Chemical Property:

• Vapor Pressure: 1.3E-07mmHg at 25°C
• Boiling Point: 430.4°C at 760 mmHg
• Flash Point: 187.7°C
• PSA: 17.07000
• Density: 1.109g/cm³
• LogP: 5.00120

Purity/Quality:

99% ^*data from raw suppliers

1,3,3-Triphenyl-2-propen-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,3,3-Triphenyl-2-propen-1-one is a reagent use in pharmaceutical synthesis such as the preparation of arylketones

Technology Process of Chalcone, .beta.-phenyl-

There total 128 articles about Chalcone, .beta.-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,1,3-triphenylprop-2-yn-1-ol (1522-13-0) → 1,3,3-triphenylprop-2-en-1-one (849-01-4)

Guidance literature:

With KSF clay; for 0.0833333h; Irradiation; microwave irradiation;

DOI:10.1039/c39890000386

Reference yield: 98.0%

1,3,3-triphenylpropan-1-one (606-86-0) → 1,3,3-triphenylprop-2-en-1-one (849-01-4)

Guidance literature:

With iodine; potassium iodide; In dimethyl sulfoxide; at 140 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c04050

Reference yield: 92.0%

iodobenzene (591-50-4) + benzalacetophenone (94-41-7) → 1,3,3-triphenylprop-2-en-1-one (849-01-4)

Guidance literature:

With palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 120 ℃; for 8h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2018.01.038

upstream raw materials:

phenylethynylmagnesium bromide

benzophenone

diethyl ether

(Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one

Downstream raw materials:

1,3,3-triphenyl-pentan-1-one

2,4,4,6-tetraphenyl-4H-1,3-oxazine

benzophenone

carbon dioxide

Refernces

• 1、 Muthusamy, Sengodagounder,Malarvizhi, Muthukumar,Suresh, Eringathodi. "Catalyst-free synthesis of 3,1-benzoxathiin-4-ones/1,3-benzodioxin-4-ones". . p. 1508 - 1513. Retrieved 2021.
• 2、 Feng, Juhua,Hu, Haipeng,Ni, Hailiang,Qiu, Yuqian,Wang, Cuilin,Wang, Guangtu,Wang, Hanguang,Wang, Wei,Wu, Xin,Yue, Guizhou,Zou, Ping. "Arylboronic Acid Catalyzed Dehydrative Mono-/Dialkylation Reactions of β-Ketoacids and Alcohols". supporting information. p. 832 - 836. Retrieved 2022/02/05.
• 3、 Yang, De-Yong,Liu, Liang,Gu, Jia-Yi,He, Yan-Hong,Guan, Zhi. "Photoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones". . p. 18042 - 18055. Retrieved 2021/12/17.